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Rocaglamide

ALX-350-121

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NF-κB inhibitor

Immunosuppressant. Potent inhibitor of NF-κB activation in T cells, with an almost complete inhibition at 200nM. Suppresses cytokine production (IFN-γ, TNF-α, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-κB and AP-1 activities. In contrast to the immunosuppressant cyclosporin A (Prod. No. BML-A195), rocaglamide does not inhibit calcineurin phosphatase activity. Induces apoptosis.

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Product Details

Alternative Name	Rocaglamide A
Appearance	White to off-white sticky solid.
CAS	84573-16-0
Couple Target	NF-kappaB
Couple Type	Inhibitor
Formula	C₂₉H₃₁NO₇
MW	505.6
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO, 100% ethanol or methanol.
Source	Synthetic

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells: S. Núñez-Vázquez, et al.; Oncogenesis 10, 64 (2021), Abstract
New acyclic bis phenylpropanoid and neolignans, from Myristica fragrans Houtt., exhibiting PARP-1 and NF-κB inhibitory effects: U.M. Acuna, et al.; Food. Chem. 202, 269 (2016), Application(s): Positive control, Abstract
Rocaglamide overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells by attenuating the inhibition of caspase-8 through cellular FLICE-like-inhibitory protein downregulation: Luan, Z., He, Y., et al.; Mol. Med. Rep. 11, 203 (2015), Abstract
Dichamanetin inhibits cancer cell growth by affecting ROS-related signaling components through mitochondrial-mediated apoptosis: Yong, Y., Matthew, S., et al.; Anticancer Res. 33, 5349 (2013), Abstract
Rocaglamide and a XIAP inhibitor cooperatively sensitize TRAIL-mediated apoptosis in Hodgkin’s lymphomas: M. Giaisi, et al.; Int. J. Cancer. 131, 1003 (2012), Abstract
Cytotoxic xanthone-anthraquinone heterodimers from an unidentified fungus of the order Hypocreales (MSX 17022): Ayers, S., Graf, T. N., et al.; J. Antibiot. (Tokyo) 65, 3 (2012), Abstract
Rocaglamide sensitizes leukemic T cells to activation-induced cell death by differential regulation of CD95L and c-FLIP expression.: J.Y. Zhu, et al.; Cell Death Differ. 16, 1289 (2009), Abstract
The traditional Chinese herbal compound rocaglamide preferentially induces apoptosis in leukemia cells by modulation of mitogen-activated protein kinase activities: J.Y. Zhu, et al.; Int. J. Cancer 121, 1839 (2007), Abstract
Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata: P. Chumkaew, et al.; Chem. Pharm. Bull. 54, 1344 (2006), Abstract
Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy: S. Kim, et al.; Anticancer Agents Med. Chem. 6, 319 (2006), Abstract

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Rocaglamide

ALX-350-121

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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