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Ro 41-5253

BML-GR110

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Retinoic acid receptor ligand

A selective RARα antagonist (concentration required to inhibit 50% of specific retinoic acid binding: RARα, 60 nM; RARß, 2400 nM; RARτ, 3300 nM). Counteracts the effects of retinoic acid on HL-60 cell differentiation, B-lymphocyte polyclonal activation and in a RARα transactivation assay. Ro 41-5253 suppresses retinoic acid-induced connexin 43 protein expression in 10T1/2 cells.

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Product Details

Appearance	White solid.
CAS	144092-31-9
Couple Target	Retinoic acid receptor
Couple Type	Ligand
Formula	C₂₈H₃₆O₅S
MW	484.7
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (50mg/ml) or 100% ethanol (15mg/ml, warm).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Involvement of hedgehog signaling in all-trans retinoic acid-mediated suppression of colon cancer: Y. Xu, et al.; Am. J. Transl. Res. 14, 6536 (2022), Abstract
Detection of retinoic acid receptor antagonist contamination in the aquatic environment of the Kinki region of Japan: D. Inoue, et al.; Water Res. 103, 58 (2016), Application(s): RAR antagonistic activity assay, Abstract
Fungus-Derived Neoechinulin B as a Novel Antagonist of Liver X Receptor, Identified by Chemical Genetics Using a Hepatitis C Virus Cell Culture System: Nakajima, S., Watashi, K., et al.; J. Virol. 90, 9058 (2016), Abstract
Azathioprine therapy selectively ablates human Vδ2+ T cells in Crohn’s disease: N.E. McCarthy, et al.; J. Clin. Invest. 125, 3215 (2015), Application(s): Cell Culture, Abstract — Full Text
The retinoic acid receptor-α modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression: Wansley, D. L., Yin, Y., et al.; Clin. Mol. Allergy 11, 4 (2013), Abstract
Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity: Nomoto, M., Takeda, Y., et al.; Mol. Brain 5, 8 (2012), Abstract
HSV-2 infection of dendritic cells amplifies a highly susceptible HIV-1 cell target: Martinelli, E., Tharinger, H., et al.; PLoS Pathog. 7, e1002109 (2011), Abstract
Cancer prevention by retinoids and carotenoids: independent action on a common target: J. S. Bertram; Biochim. Biophys. Acta. 1740, 170 (2005), Abstract
Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping: S. Keidel et al.; Mol. Cell. Biol. 14, 287 (1994), Abstract

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Ro 41-5253

BML-GR110

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