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Ro 31-8220

BML-EI283

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PKC inhibitor

Cell-permeable PKC inhibitor. Selective for PKC (IC₅₀=10nM) over CaM kinase II (IC₅₀=17µM) and PKA (IC₅₀=0.9µM). Induces apoptosis in various cell lines.

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Product Details

Alternative Name	2-[1-(3-(Amidinothio)propyl)-1H-indol-3-yl]-3-(1-methylindol-3-yl)maleimide·methanesulfonate, Bisindolylmaleimide IX . Methanesulfonate
Appearance	Red/orange solid.
CAS	138489-18-6
Couple Target	PKC
Couple Type	Inhibitor
Formula	C₂₅H₂₃N₅O₂S·CH₄O₃S
MW	553.7
Purity	≥98%
Solubility	Soluble in DMSO (10mg/ml)

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The rapid activation of cPKCβII by progesterone results in the negative regulation of Ca 2+ influx in human resting T cells: V.H.C. Lin, et al.; J. Chin. Med. Assoc. , (2023), Abstract
From blue light to clock genes in zebrafish ZEM-2S cells: Ramos, B. C., Moraes, M. N., et al.; PLoS One 9, e106252 (2014), Application(s): In Vitro, Abstract
A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells: Roose, J. P., Mollenauer, M., et al.; Mol. Cell. Biol. 25, 4426 (2005), Abstract
T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression: Roose, J. P., Diehn, M., et al.; PLoS Biol. 1, E53 (2003), Abstract
Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth factor-1-binding protein-3.: L. Shen & R.I. Glazer; Biochem. Pharmacol. 55, 1711 (1998), Abstract
Atypical isoforms of pKc and insulin secretion from pancreatic beta-cells: evidence using Go 6976 and Ro 31-8220 as Pkc inhibitors.: T.E. Harris et al.; Biochem. Biophys. Res. Commun. 227, 672 (1996), Abstract
Differential inhibition of cytosolic and membrane-derived protein kinase C activity by staurosporine and other kinase inhibitors.: J. Budworth & A. Gescher; FEBS Lett. 362, 139 (1995), Abstract
Inhibition by Ro 31-8220 of acid secretory activity induced by carbachol indicates a stimulatory role for protein kinase C in the action of muscarinic agonists on isolated rat parietal cells.: J.P. McKenna & P.J. Hanson; Biochem. Pharmacol. 46, 583 (1993), Abstract
Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C.: S.E. Wilkinson et al.; Biochem. J. 294, 335 (1993), Abstract
Characterisation of protein kinase C isoforms and enzymic activity from the alpha T3-1 gonadotroph-derived cell line.: M.S. Johnson et al.; FEBS Lett. 333, 67 (1993), Abstract

Last modified: May 29, 2024

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Ro 31-8220

BML-EI283

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