RITA

ALX-430-151

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Inhibitor of p53/HDM2 interaction

Inhibitor of p53/HDM2 interaction. Activator of p53 function in tumors. Potently inhibits the growth of a variety of cancer cell lines in the submicromolar range. It has been suggested that RITA selectively targets cells expressing p53 by other mechanisms than direct binding to the N-terminal domain of p53.

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Product Details

Alternative Name	Reactivation of p53 and Induction of Tumor Cell Apoptosis, 2,5-bis(5-Hydroxymethyl-2-thienyl)furan, NSC652287
Appearance	White to brown crystalline solid.
CAS	213261-59-7
Formula	C₁₄H₁₂O₃S₂
MW	292.4
Purity	≥98% (HPLC)
Solubility	Soluble in 100% ethanol (1mg/ml), DMSO (20mg/ml), dimethyl formamide (30mg/ml); 0.5mg/ml soluble in a 1:1 solution of dimethyl formamide: PBS (pH 7.2) (dissolve RITA first in dimethyl formamide and then dilute with PBS).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least two years after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro: M. Krajewski, et al.; Nat. Med. 11, 1135 (2005), Abstract
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors: N. Issaeva, et al.; Nat. Med. 10, 1321 (2004), Abstract
DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells: W. Nieves-Neira, et al.; Mol. Pharmacol. 56, 478 (1999), Abstract — Full Text
Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism: M.I. Rivera, et al.; Biochem. Pharmacol. 57, 1283 (1999), Abstract

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RITA

ALX-430-151

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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