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Ristocetin A . sulfate

ALX-380-237

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Antibiotic. Inducer of platelet aggregation

Potent antibacterial antibiotic. Induces platelet aggregation by binding to a factor absent in people suffering from von Willebrand’s disease and is therefore an important diagnostic tool. Chiral selector for the separation of enantiomers by HPLC, TLC and electrophoresis.

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Product Details

Alternative Name	Ristocetin . sulfate, Ristomycin III . sulfate, Spontin . sulfate, Riston . sulfate
Appearance	Light tan solid.
CAS	11140-99-1
Formula	C₉₅H₁₁₀N₈O₄₄. H₂SO₄
MI	14: 8234
MW	2067.9 . 98.1
Purity	≥95% (HPLC)
RTECS	VJ8595000
Solubility	Soluble in water, methanol or DMSO.
Source	Isolated from Amycolatopsis sp. MST-AS5924.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

HPLC separation of amino acid enantiomers and small peptides on macrocyclic antibiotic-based chiral stationary phases: a review: I. Ilisz, et al.; J. Sep. Sci. 29, 1305 (2006), (Review), Abstract
A peptide isolated from alpha B-crystallin is a novel and potent inhibitor of platelet aggregation via dual prevention of PAR-1 and GPIb/V/IX: H. Matsuno, et al.; J. Thromb. Haemost. 1, 2636 (2003), Abstract
Cooperativity and anti-cooperativity between ligand binding and the dimerization of ristocetin A: asymmetry of a homodimer complex and implications for signal transduction: Y.R. Cho, et al.; Chem. Biol. 3, 207 (1996), Abstract
Ristocetin–a new tool in the investigation of platelet aggregation: M.A. Howard and B.G. Firkin; Thromb. Diath. Haemorrh. 26, 362 (1971), Abstract
Ristocetin A and B, two new antibiotics. Isolation and properties: J.E. Philip, et al.; Antibiot. Annu. 1956-1957, 699 (1957)

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Ristocetin A . sulfate

ALX-380-237

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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