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Rifampicin

ALX-380-071

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Bacterial DNA-dependent RNA polymerase inhibitor

A selective inhibitor of bacterial DNA-dependent RNA polymerase (RNAP). Has no effect on mammalian RNA polymerase. The RNAP-rifampicin complex locks the promoter in an abortive initiation reaction making short oligoribonucleotides which diffuse out of the active site. Inhibits α-synuclein fibrillation and disaggregates fibrils. Potent inducer of hepatic cytochrome P450 enzymes.

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Product Details

Alternative Name	Rifampin, 3-(4-Methylpiperazinyl-iminomethyl)rifamycin SV
Appearance	Orange to brown powder.
CAS	13292-46-1
Couple Target	Bacterial DNA-dependent RNA polymerase
Couple Type	Inhibitor
Formula	C₄₃H₅₈N₄O₁₂
MI	14: 8216
MW	823.0
Purity	≥97% (Assay)
RTECS	VJ7000000
Solubility	Soluble in DMSO (25mg/ml) or methanol (25mg/ml).
Source	Semisynthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor: J. Chen and K. Raymond; Ann. Clin. Microbiol. Antimicrob. 50, 3 (2006), Review, Abstract
Rifampicin inhibits alpha-synuclein fibrillation and disaggregates fibrils: J. Li, et al.; Chem. Biol. 11, 1513 (2004), Abstract
Pharmacokinetic interactions with rifampicin : clinical relevance: M. Niemi, et al.; Clin. Pharmacokinet. 42, 819 (2003), Review, Abstract
Rifampicin region revisited. New rifampicin-resistant and streptolydigin-resistant mutants in the beta subunit of Escherichia coli RNA polymerase: K. Severinov, et al.; J. Biol. Chem. 268, 14820 (1993), Abstract
Pharmacokinetic drug interactions with rifampicin: K. Venkatesan; Clin. Pharmacokinet. 22, 47 (1992), Review, Abstract
On the mechanism of rifampicin inhibition of RNA synthesis: W.R. McClure and C.L. Cech; J. Biol. Chem. 253, 8949 (1978), Abstract
Chemical and biological properties of rifampicin: S. Furesz; Antibiot. Chemother. 16, 316 (1970), Abstract
Rifampicin sensitivity of the components of DNA-dependent RNA polymerase: E. di Mauro, et al.; Nature 222, 533 (1969), Abstract
Rifampicin: a new orally active rifamycin: N. Maggi, et al.; Chemotherapy 11, 285 (1966), Abstract

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Rifampicin

ALX-380-071

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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