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RICK polyclonal antibody

ADI-AAP-460

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The RICK (Receptor-interacting serine/threonine protein kinase 2) protein, also known as RIP-like interacting CLARP kinase, and CARD-containing ICE associated kinase, contains an N-terminal kinase domain and a C-terminal CARD domain. Overexpression of RICK results in the activation of NF-κB pathway and also induces apoptosis. RICK represents a kinase that regulates TNF and Fas induced-apoptosis and that is involved in the generation of proinflammatory cytokine IL-1beta.

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This antibody is covered by our Worry-Free Guarantee.

RICK polyclonal antibody Immunocytochemistry — Immunocytochemistry analysis of RICK in A431 cells with RICK antibody at 10µg/ml.

RICK polyclonal antibody Western blot — Western blot analysis of RICK in A431 (A) and K562 (K) whole cell lysate with RICK antibody at 1:1000 dilution.

Product Details

Alternative Name	RIP2, CARDIAK, CARD-containing interleukin-1β converting enzyme associated kinase, RIPK2, Receptor-interacting serine/threonine protein kinase 2, Receptor-interacting protein 2
Application	ICC, IP, WB
Formulation	Liquid. In PBS containing 0.02% sodium azide.
GenBank ID	AF027706
Host	Rabbit
Immunogen	Synthetic peptide corresponding to the sequence near the N-terminus of human RICK.
Purity Detail	Peptide affinity purified.
Recommendation Dilutions/Conditions	Immunocytochemistry (10µg/ml)Western Blot (0.5-1.0µg/ml, ECL)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Species Reactivity	Human, Mouse, Rat
UniProt ID	O43353
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Neurotrophin Analog ENT-A044 Activates the p75 Neurotrophin Receptor Promoting Cell Death in Mouse and Human Neuronal Cells: Papadopoulou, M. A., Rogdakis, T., et al.; Preprints.org , (2023)
Neurotrophin Analog ENT-A044 Activates the p75 Neurotrophin Receptor, Regulating Neuronal Survival in a Cell Context-Dependent Manner: Papadopoulou, M. A., Rogdakis, T., et al.; Int. J. Mol. Sci. 24, (2023), Abstract
BNN27, a 17-Spiroepoxy Steroid Derivative, Interacts With and Activates p75 Neurotrophin Receptor, Rescuing Cerebellar Granule Neurons from Apoptosis: Pediaditakis, I., Kourgiantaki, A., et al.; Front. Pharmacol. 7, 512 (2017), Abstract
Differential effects of dehydroepiandrosterone and testosterone in prostate and colon cancer cell apoptosis: the role of nerve growth factor (NGF) receptors: Anagnostopoulou, V., Pediaditakis, I., et al.; Endocrinology 154, 2446 (2013), Abstract
A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2: M.V. Chao, et al.; J. Neurosci. 21, 5854 (2001), Application(s): IP using rat samples, Abstract

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RICK polyclonal antibody

ADI-AAP-460

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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