RHC-80267

BML-ST300

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Diacylglycerol lipase inhibitor

Diacylglycerol (DAG) is an important cellular source of arachidonate which may be released by the action of DAG lipase. RHC-80267 selectively inhibits DAG lipase activity in canine platelets (IC₅₀=4 µM), bovine adrenal chromaffin cells, human adrenal glomerulosa cells, rat thyroid lobes and pancreatic minilobules.

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Product Details

Alternative Name	U-57908, 1,6-bis-(Cyclohexyloximinocarbonylamino)-hexane
Appearance	White to off-white solid.
CAS	83654-05-1
Couple Target	Diacylglycerol lipase
Couple Type	Inhibitor
Formula	C₂₀H₃₄N₄O₄
MW	394.6
MeltingPoint	118-121°C
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Cytosolic Phospholipase A2α Promotes Pulmonary Inflammation and Systemic Disease during Streptococcus pneumoniae Infection: Bhowmick, R., Clark, S., et al.; Infect. Immun. 85, (2017), Abstract
Endocannabinoid-dependent LTD in a nociceptive synapse requires activation of a presynaptic TRPV-like receptor: Yuan, S., Burrell, B. D., et al.; J. Neurophysiol. 104, 2766 (2010), Abstract
Arachidonic acid release from diacylglycerol in human neutrophils. Translocation of diacylglycerol-deacylating enzyme activities from an intracellular pool to plasma membrane upon cell activation: J. Balsinde, et al.; J. Biol. Chem. 266, 15638 (1991), Abstract
Arachidonic acid liberated by diacylglycerol lipase is essential for the release mechanism in chromaffin cells from bovine adrenal medulla: B. Rindlisbacher, et al.; J. Neurochem. 54, 1247 (1990), Abstract
Diacylglycerol provides arachidonic acid for lipoxygenase products that mediate angiotensin II-induced aldosterone synthesis: R. Natarajan, et al.; Biochem. Biophys. Res. Commun. 156, 717 (1988), Abstract
Inhibitors of diacylglycerol lipase and diacylglycerol kinase inhibit carbamylcholine-stimulated responses in guinea pig pancreatic minilobules: M.C. Sekar & L.E. Hokin; Arch. Biochem. Biophys. 256, 509 (1987), Abstract
RHC 80267 inhibits thyrotropin-stimulated prostaglandin release from rat thyroid lobes: S. Levasseur, et al.; Prostaglandins 27, 673 (1984), Abstract
Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. Selective inhibition of diglyceride lipase by RHC 80267: C.A. Sutherland & D. Amin; J Biol Chem 257, 14006 (1982), Abstract

Last modified: May 29, 2024

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RHC-80267

BML-ST300

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