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The RGMC (also called Hemojuvelin) is a GPI-anchored protein involved in iron metabolism through regulation of hepcidin expression. Mutations in the gene encoding RGMC cause severe iron overload (juvenile hemochromatosis /hemochromatosis type 2A). The protein binds to neogenin and acts as co-receptor of the bone morphogenetic protein. The mature RGMc protein is proteolytically processed and glycosylated.
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Flow cytometry analysis of HEK293 cells stably overexpressing RGMC stained with RGMC (human), mAb (1D7) [Prod no. ENZ-ABS258] at 1:100 dilution (blue line) or normal mouse IgG (control, purple line).
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RUO – Research Use Only |
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