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RGD peptide

BML-P700

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Integrin ligand

Induces apoptosis in various cell types and cell lines at 1mM by a mechanism involving cellular uptake and possible direct stimulation of procaspase-3 autoprocessing. Does not induce apoptosis in the breast cancer line MCF-7, in which there is a functional deletion of the procaspase-3 gene. Contains the motif RGD (Arg-Gly-Asp) which is found in many integrin ligands. Inhibits cell adhesion of COS-7 cells to fibronectin 80-90% at 1mM.

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Product Details

Alternative Name	GRGDNP
Appearance	Solid.
CAS	114681-65-1
Formulation	Lyophilized.
MW	614.6
Purity	≥97% (HPLC)
Sequence	Gly-Arg-Gly-Asp-Asn-Pro
Solubility	Soluble in water (>50mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Acute high-fat diet impairs macrophage supported intestinal damage resolution: A.A. Hill, et al.; JCI Insight 8, e164489 (2023), Abstract
The actin cytoskeleton-MRTF/SRF cascade transduces cellular physical niche cues to entrain the circadian clock: X. Xiong, et al.; J. Cell Sci. 135, jcs260094 (2022), Abstract
Pancreatic cancer cells render tumor-associated macrophages metabolically reprogrammed by a GARP and DNA methylation-mediated mechanism: M. Zhang, et al.; Signal Transduct. Target Ther. 6, 366 (2021), Abstract
β1 integrins mediate attachment of mesenchymal stem cells to cartilage lesions: D. Zwolanek, et al.; Biores. Open Access 4, 39 (2015), Application(s): Cell treatment, Abstract — Full Text
Cortical actin regulation modulates vascular contractility and compliance in veins: R.J. Saphirstein, et al.; J. Physiol. 593, 3929 (2015), Application(s): Coupling to magnetic beads, Abstract — Full Text
Vascular endothelial cells promote cortical neurite outgrowth via an integrin β3-dependent mechanism: S. Sumimoto, et al.; Biochem. Biophys. Res. Commun. 450, 593 (2014), Application(s): Cell treatment, Abstract
Kindlin-1 regulates mitotic spindle formation by interacting with integrins and Plk-1: H. Patel, et al.; Nat. Commun. 4, 2056 (2013), Application(s): Cell treatment / Reactant(s): Human, Abstract
The focal adhesion: a regulated component of aortic stiffness: R.J. Saphirstein, et al.; PLoS One 8, e62461 (2013), Application(s): Coupling to magnetic beads, Abstract
Endothelial-derived thrombospondin-1 promotes macrophage recruitment and apoptotic cell clearance: T. Kirsch, et al.; J. Cell. Mol. Med. 14, 1922 (2010), Application(s): Cell treatment, Abstract — Full Text
RGD peptides induce apoptosis by direct caspase-3 activation: C. D. Buckley et al.; Nature 397, 534 (1999), Abstract

Last modified: May 29, 2024

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RGD peptide

BML-P700

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