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Immunosuppressant
- Antibiotic with immunosuppressant and anti-cancer properties
- Commonly used to study autophagy in a variety of cells
- Highly cited
Rapamycin is a macrocyclic-triene antibiotic with potent immunosuppressant activity. Rapamycin forms a complex with FKBP12 that binds to an effector, thus inhibiting IL-2 and other growth promoting lymphokines. The effectors were identified as FRAP (FKBP12 rapamycin-associated protein) and RAFT1 (rapamycin and KFBP12 target). Rapamycin/FKBP complex does not inhibit FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin induces inhibition of p70s6k, p33cdk2 and p34cdc2. Rapamycin selectively blocks signaling leading to the activation of p70/85 S6 kinase. Rapamycin complexed with FKBP12 binds to and inhibits the activity of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1). Rapamycin can inhibit cell growth, enhance apoptosis, and activates autophagy in a variety of cell types.
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Product Details
| Alternative Name |
Sirolimus, AY-22,989, RAPA, Rapamune |
|---|---|
| Appearance |
Off-white or yellow solid. |
| CAS |
53123-88-9 |
| Couple Target |
Immunophilin, mTOR |
| Couple Type |
Inhibitor, Ligand |
| Formula |
C51H79NO13 |
| MI |
14: 8114 |
| MW |
914.2 |
| Purity |
≥98% (HPLC) |
| RTECS |
VE6250000 |
| Solubility |
Soluble in chloroform, DMSO (25mg/ml), or 100% methanol. |
| Source |
Isolated from Streptomyces hygroscopus |
| Technical Info / Product Notes |
Replacement for ADI-HPK-109. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
|---|---|
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Alternative autophagy dampens UVB-induced NLRP3 inflammasome activation in human keratinocytes: Hasegawa, T., Noguchi, S., et al.; J. Biol. Chem. 300, 107173 (2024), Abstract
- FoxO transcription factors actuate the formative pluripotency specific gene expression programme: Santini, L., Kowald, S., et al.; Nat. Commun. 15, 7879 (2024), Abstract
- STAT1 Promotes PD-L1 Activation and Tumor Growth in Lymphangioleiomyomatosis: Olatoke, T., Zhang, E. Y., et al.; bioRxiv , (2024)
- Streptococcal arginine deiminase regulates endothelial inflammation, mTOR pathway and autophagy: J.T. Mammedova, et al.; Immunobiology 228, 152344 (2023), Abstract
- Defective quality control autophagy in Hyperhomocysteinemia promotes ER stress and consequent neuronal apoptosis through proteotoxicity: B. Kaur, et al.; Cell Commun. Signal. 21, 258 (2023), Abstract
- Incongruence between transcriptional and vascular pathophysiological cell states: Fernández-Chacón, M., Mühleder, S., et al.; Nat. Cardiovasc. Res. 2, 2023530 (2023), Abstract
- The methyltransferase enzymes KMT2D, SETD1B, and ASH1L are key mediators of both metabolic and epigenetic changes during cellular senescence: T. Nacarelli, et al.; Mol. Biol. Cell 33, ar36 (2022), Abstract
- An amino acid-defined diet impairs tumour growth in mice by promoting endoplasmic reticulum stress and mTOR inhibition: M. Ragni, et al.; Mol. Metab. 60, 101478 (2022), Abstract
- Ipecac root extracts and isolated circular peptides differentially suppress inflammatory immune response characterised by proliferation, activation and degranulation capacity of human lymphocytes in vitro: C.M. Falanga, et al.; Biomed. Pharmacother. 152, 113120 (2022), Abstract
- Impaired degradation of YAP1 and IL6ST by chaperone-mediated autophagy promotes proliferation and migration of normal and hepatocellular carcinoma cells: E. Desideri, et al.; Autophagy , (2022), Abstract
- Fluorescence imaging detection of nanodomain redox signaling events at organellar contacts: D.M. Booth, et al.; STAR Protoc. 3, 101119 (2022), Abstract — Full Text
- Microtubule organizing centers regulate spindle positioning in mouse oocytes: D. Londono-Vasquez, et al.; Dev. Cell 57, 197 (2022), Abstract
- NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation: M. Huth, et al.; Genes Dev. 36, 348 (2022), Abstract — Full Text
- RAPIDS, a method for sub-compartmental identification of protein interactomes: C. James, et al.; Methods Enzymol. 675, 109 (2022), Abstract
- Rgs16 promotes antitumor CD8+ T cell exhaustion: N. Weisshaar, et al.; Sci. Immunol. 7, eabh1873 (2022), Abstract
- The autophagy protein Pacer positively regulates the therapeutic potential of mesenchymal stem cells in a mouse model of DSS-induced colitis: C. Bergmann, et al.; Cells 11, 1503 (2022), Abstract — Full Text
- Enhanced protein synthesis is a defining requirement for neonatal B cell development: Åkerstrand, H., Boldrin, E., et al.; bioRxiv , (2022)
- Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient-Derived Neurons: Z. Hanss, et al.; Mov. Disord. 36, 704 (2021), Application(s): Treatment of iPSCs-derived neurons, Abstract — Full Text
- Carbon Monoxide Releasing Molecule-3 Enhances Heme Oxygenase-1 Induction via ROS-Dependent FoxO1 and Nrf2 in Brain Astrocytes: C. C. Lin, et al.; Oxid. Med. Cell. Longev. 2021, 5521196 (2021), Abstract
- Autophagy-Associated IL-15 Production Is Involved in the Pathogenesis of Leprosy Type 1 Reaction: B.J.A. Silva, et al.; Cells 10, 2215 (2021), Abstract
- The selective degradation of sirtuins via macroautophagy in the MPP+ model of Parkinson’s disease is promoted by conserved oxidation sites: M.W. Baeken, et al.; Cell Death Discov. 7, 286 (2021), Abstract
- Distinct alpha-Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH-SY5Y cells: M. Pantazopoulou, et al.; J. Neurochem. 156, 880 (2021), Abstract
- Oxidative bursts of single mitochondria mediate retrograde signaling toward the ER: D. Booth, et al.; Mol. Cell 81, 3866 (2021), Abstract — Full Text
- Raft-like lipid microdomains drive autophagy initiation via AMBRA1-ERLIN1 molecular association within MAMs: V. Manganelli, et al.; Autophagy 17, 2528 (2021), Abstract — Full Text
- Receptor-mediated endocytosis 8 (RME-8)/DNAJC13 is a novel positive modulator of autophagy and stabilizes cellular protein homeostasis: A. Besemer, et al.; Cell. Mol. Life Sci. 78, 645 (2021), Abstract — Full Text
- Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response: S.J. Jeong, et al.; Autophagy 17, 3740 (2021), Abstract — Full Text
- Rejection of xenogeneic porcine islets in humanized mice is characterized by graft-infiltrating Th17 cells and activated B cells: F.T. Lee, et al.; Am. J. Transplant. 20, 1538 (2020), Abstract — Full Text
- Pharmacological inhibition of mTORC1 increases CCKBR-specific tumor uptake of radiolabeled minigastrin analogue [ 177 Lu]Lu-PP-F11N: M. Grzmil, et al.; Theranostics 10, 10861 (2020), Abstract — Full Text
- Incorporation of docetaxel and thymoquinone in borage nanoemulsion potentiates their antineoplastic activity in breast cancer cells: M.H. Alkhatib, et al.; Sci. Rep. 10, 18124 (2020), Abstract — Full Text
- Lipid-droplet formation drives pathogenic group 2 innate lymphoid cells in airway inflammation: F. Karagiannis, et al.; Immunity 52, 620 (2020), Abstract
- Lymphatics in bone arise from pre-existing lymphatics: M. Monroy, et al.; Development 147, dev184291 (2020), Abstract — Full Text
- Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A: R. Svarcbahs, et al.; Pharmacol. Res. 151, 104558 (2020), Abstract
- RAB18 loss interferes with lipid droplet catabolism and provokes autophagy network adaptations: F. Bekbulat, et al.; J. Mol. Biol. 432, 1216 (2020), Abstract
- Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance: S. Kim, et al.; Autophagy 16, 1200 (2020), Abstract — Full Text
- The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy: T. Kilpelainen, et al.; Biomed. Pharmacother. 128, 110253 (2020), Abstract
- UFMylation regulates translational homeostasis and cell cycle progression: Gak, I. A., Vasiljevic, D., et al.; bioRxiv , (2020)
- Effect of selective serotonin (5-HT)2B receptor agonist BW723C86 on epidermal growth factor/transforming growth factor-α receptor tyrosine kinase and ribosomal p70 S6 kinase activities in primary cultures of adult rat hepatocytes: K. Naito, et al.; Biol. Pharm. Bull. 42, 631 (2019), Application(s): used w. adult rat liver hepatocytes, Abstract — Full Text
- Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis: S. Beltran, et al.; Mol. Neurodegener. 14, 14 (2019), Abstract — Full Text
- Fas‐apoptotic inhibitory molecule 2 localizes to the lysosome and facilitates autophagosome‐lysosome fusion through the LC3 interaction region motif–dependent interaction with LC3: C.J. Hong, et al.; FASEB J. 34, 161 (2019), Abstract — Full Text
- Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial: C. Chung, et al.; Geroscience 41, 861 (2019), Abstract — Full Text
- Nemo-like kinase drives Foxp3 stability and is critical for maintenance of immune tolerance by regulatory T cells: V. Fleskens, et al.; Cell Rep. 26, 3600 (2019), Abstract — Full Text
- CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence: C. Crochemore, et al.; Nat. Commun. 10, 5576 (2019), Abstract — Full Text
- Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress: D. Chakraborty, et al.; Redox Biol. 24, 101181 (2019), Abstract — Full Text
- Linagliptin inhibits high glucose-induced transdifferentiation of hypertrophic scar-derived fibroblasts to myofibroblasts via IGF/Akt/mTOR signalling pathway: Y. Li, et al.; Exp. Dermatol. 28, 19 (2019), Abstract
- Loss of neurological disease HSAN-I-associated gene SPTLC2 impairs CD8+ T cell responses to infection by inhibiting T cell metabolic fitness: J. Wu, et al.; Immunity 50, 1218 (2019), Abstract — Full Text
- Promoter distortion and opening in the RNA polymerase II cleft: C. Dienemann, et al.; Mol. Cell 73, 97 (2019), Abstract
- Somatic activating mutations in PIK3CA cause generalized lymphatic anomaly: L. Rodriguez-Laguna, et al.; J. Exp. Med. 216, 407 (2019), Abstract — Full Text
- TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia: J.W. Lee, et al.; Autophagy 15, 753 (2019), Abstract — Full Text
- Peripheral Synthesis of an Atypical Protein Kinase C Mediates the Enhancement of Excitability and the Development of Mechanical Hyperalgesia Produced by Nerve Growth Factor: J. Kays, et al.; Neuroscience 371, 420 (2018), Abstract
- LXRɑ participates in the mTOR/S6K1/SREBP-1c signaling pathway during sodium palmitate-induced lipogenesis in HepG2 cells: Y. Zhou, et al.; Nutr. Metab. (Lond.) 15, 31 (2018), Abstract — Full Text
- Locally Produced IGF-1 Promotes Hypertrophy of the Ligamentum Flavum via the mTORC1 Signaling Pathway: B. Yan, et al.; Cell. Physiol. Biochem. 48, 293 (2018), Abstract — Full Text
- Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells: S. Zielke, et al.; Cell Death Dis. 9, 994 (2018), Abstract — Full Text
- An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion: Baumgartner, C., Toifl, S., et al.; Cell Stem Cell 22, 879 (2018), Abstract
- RAB18 impacts autophagy via lipid droplet-derived lipid transfer and is rescued by ATG9A: Bekbulat, F., Schmitt, D., et al.; bioRxiv , (2018)
- The RAB GTPase RAB18 modulates macroautophagy and proteostasis: A. Feldmann, et al.; Biochem. Biophys. Res. Commun. 486, 738 (2017), Abstract
- Discovery of pan autophagy inhibitors through a high-throughput screen highlights macroautophagy as an evolutionarily conserved process across 3 eukaryotic kingdoms: Mishra, P., Dauphinee, A. N., et al.; Autophagy 13, 1556 (2017), Abstract
- The Use of DQ-BSA to Monitor the Turnover of Autophagy-Associated Cargo: Frost, L. S., Dhingra, A., et al.; Methods Enzymol. 587, 43 (2017), Abstract
- An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response: A. De Gassart, et al.; PNAS 113, E117 (2016), Application(s): Cell culture, Abstract — Full Text
- Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A: C. Xu, et al.; Neuropharmacology 105, 270 (2016), Application(s): Cell culture, Abstract
- IL-2, IL-4, IFN-γ or TNF-α enhances BAFF-stimulated cell viability and survival by activating Erk1/2 and S6K1 pathways in neoplastic B-lymphoid cells: L. Gui, et al.; Cytokine 84, 37 (2016), Application(s): Cell culture, Abstract
- Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis: H. Pan, et al.; BMC Biochem. 17, 14 (2016), Application(s): Immunofluorescence microscopy – involvement in cell cycle processes, Abstract — Full Text
- Transforming Growth Factor-β1 Increases DNA Methyltransferase 1 and -3a Expression Through Distinct Post-transcriptional Mechanisms in Lung Fibroblasts: H.B. Koh, et al.; J. Biol. Chem. 291, 19287 (2016), Application(s): Cell culture; mTOR inhibitor, normal primary human lung fibroblasts, Abstract — Full Text
- Serotonin 5-HT2B Receptor-Stimulated DNA Synthesis and Proliferation Are Mediated by Autocrine Secretion of Transforming Growth Factor-α in Primary Cultures of Adult Rat Hepatocytes: K. Naito, et al.; Biol. Pharm. Bull. 39, 570 (2016), Application(s): Effects of Various Doses of Selective 5-HT2 Receptor Antagonists on DNA Synthesis and Proliferation in Hepatocytes, Abstract — Full Text
- Lutein Attenuates Both Apoptosis and Autophagy upon Cobalt (II) Chloride-Induced Hypoxia in Rat Műller Cells: F.K. Fung, et al.; PLoS One 11, e0167828 (2016), Abstract
- Caspase-mediated cleavage of raptor participates in the inactivation of mTORC1 during cell death: Martin, R., Desponds, C., et al.; Cell Death Discov. 2, 16024 (2016), Abstract
- Chronic Repression of mTOR Complex 2 Induces Changes in the Gut Microbiota of Diet-induced Obese Mice: Jung, M. J., Lee, J., et al.; Sci. Rep. 6, 30887 (2016), Abstract
- Zoledronate Attenuates Accumulation of DNA Damage in Mesenchymal Stem Cells and Protects Their Function: Misra, J., Mohanty, S. T., et al.; Stem Cells 34, 756 (2016), Abstract
- Induction of apoptosis and autophagy via sirtuin1- and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate cancer cells: Z.W. Zhou, et al.; Drug Des. Devel. Ther. 9, 1511 (2015), Application(s): Cell Culture, Assay, Abstract — Full Text
- Glutamate Stimulates Local Protein Synthesis in the Axons of Rat Cortical Neurons by Activating AMPA Receptors and Metabotropic Glutamate Receptors: W.L. Hsu, et al.; J. Biol. Chem. 390, 20748 (2015), Application(s): Cell Culture, Abstract — Full Text
- ILT4 drives B7-H3 expression via PI3K/AKT/mTOR signalling and ILT4/B7-H3 co-expression correlates with poor prognosis in non-small cell lung cancer: P. Zhang, et al.; FEBS Lett. 589, 2248 (2015), Application(s): Cell Culture, Abstract
- Cinnamic aldehyde suppresses hypoxia-induced angiogenesis via inhibition of hypoxia-inducible factor-1α expression during tumor progression: W.Y. Bae, et al.; Biochem. Pharmacol. 98, 41 (2015), Application(s): Cell culture , Abstract
- Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A: P.M. Wong, et al.; Nat. Commun. 6, 8048 (2015), Application(s): Cell Culture, Abstract — Full Text
- Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis: Kindrachuk, J., Ork, B., et al.; Antimicrob. Agents Chemother. 59, 1088 (2015), Abstract
- Aurantiamide acetate suppresses the growth of malignant gliomas in vitro and in vivo by inhibiting autophagic flux: Yang, Y., Zhang, L. H., et al.; J. Cell. Mol. Med. 19, 1055 (2015), Abstract
- Long-term live imaging reveals cytosolic immune responses of host hepatocytes against Plasmodium infection and parasite escape mechanisms: Prado, M., Eickel, N., et al.; Autophagy 11, 1561 (2015), Abstract
- Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy: Jabir, M. S., Hopkins, L., et al.; Autophagy 11, 166 (2015), Abstract
- mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer: Sodi, V. L., Khaku, S., et al.; Mol. Cancer Res. 13, 923 (2015), Abstract
- Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy: Valianou, M., Cox, A. M., et al.; Cell Cycle 14, 399 (2015), Abstract
- Ubiquitinated proteins enriched from tumor cells by a ubiquitin binding protein Vx3(A7) as a potent cancer vaccine: Aldarouish, M., Wang, H., et al.; J. Exp. Clin. Cancer Res. 34, 34 (2015), Abstract
- Coxiella burnetii Type IV Secretion-Dependent Recruitment of Macrophage Autophagosomes: C.G. Winchell, et al.; Infect. Immun. 82, 2229 (2014), Application(s): Role of the T4SS in mediating PV interactions with autophagosomes, Abstract
- Acute focal brain damage alters mitochondrial dynamics and autophagy in axotomized neurons: Cavallucci, V., Bisicchia, E., et al.; Cell Death Dis. 5, e1545 (2014), Abstract
- Ovothiol isolated from sea urchin oocytes induces autophagy in the Hep-G2 cell line: Russo, G. L., Russo, M., et al.; Mar. Drugs 12, 4069 (2014), Abstract
- RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy: Spang, N., Feldmann, A., et al.; Autophagy 10, 2297 (2014), Abstract
- Anti-tumor efficacy of a hepatocellular carcinoma vaccine based on dendritic cells combined with tumor-derived autophagosomes in murine models: S. Su, et al.; Asian Pac. J. Cancer Prev. 14, 3109 (2013), Application(s): WB, Fluorescence Microscopy, PCR, Abstract — Full Text
- Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts: C. Lerner, et al.; Aging Cell 12, 966 (2013), Application(s): WB, Abstract — Full Text
- Rapamycin decreases tau phosphorylation at Ser214 through regulation of cAMP-dependent kinase: Y. Liu, et al.; Neurochem. Int. 62, 458 (2013), Application(s): WB, IP, Confocal microscopy, Abstract
- Direct imaging reveals stable, micrometer-scale lipid domains that segregate proteins in live cells: A. Toulmay; J. Cell Biol. 202, 35 (2013), Application(s): Fluorescence Microscopy, Abstract — Full Text
- Remarkable inhibition of mTOR signaling by the combination of rapamycin and 1,4-phenylenebis(methylene)selenocyanate in human prostate cancer cells: N.D. Facompre, et al.; Int. J. Cancer 131, 2134 (2013), Application(s): WB, IP, Abstract — Full Text
- Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line: I. Tedesco, et al.; Food Chem. Toxicol. 60, 377 (2013), Application(s): WB, Fluorescence Microscopy, Abstract
- IRAK4 turns IL-10+ phospho-FOXO+ monocytes into pro-inflammatory cells by suppression of protein kinase B: Over, B., Ziegler, S., et al.; Eur. J. Immunol. 43, 1630 (2013), Abstract
- p62/SQSTM1-dependent autophagy of Lewy body-like α-synuclein inclusions: Watanabe, Y., Tatebe, H., et al.; PLoS One 7, e52868 (2013), Abstract
- Renal cancer-selective Englerin A induces multiple mechanisms of cell death and autophagy: Williams, R. T., Yu, A. L., et al.; J. Exp. Clin. Cancer Res. 32, 57 (2013), Abstract
- A conserved membrane-binding domain targets proteins to organelle contact sites: Toulmay, A., Prinz, W. A., et al.; J. Cell Sci. 125, 49 (2012), Abstract
- Glutathione participates in the modulation of starvation-induced autophagy in carcinoma cells: Desideri, E., Filomeni, G., et al.; Autophagy 8, 1769 (2012), Abstract
- Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage: Viscomi, M. T., D’Amelio, M., et al.; Autophagy 8, 222 (2012), Abstract
- Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer: C.G. Sanchez, et al.; Breast Cancer Res. 13, R21 (2011), Application(s): WB, Abstract — Full Text
- Regulatory T cells require mammalian target of rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice: Wang, Y., Camirand, G., et al.; J. Immunol. 186, 2809 (2011), Abstract
- Vertical inhibition of the mTORC1/mTORC2/PI3K pathway shows synergistic effects against melanoma in vitro and in vivo: Werzowa, J., Koehrer, S., et al.; J. Invest. Dermatol. 131, 495 (2011), Abstract
- Long-Term IGF-I Exposure Decreases Autophagy and Cell Viability: A. Bitto, et al.; PloS One 5, e12592 (2010), Application(s): WB, Fluorescence Microscopy, Electron Microscopy , Abstract — Full Text
- VEGF induces expression of Bcl-2 and multiple signaling factors in microvascular endothelial cells in a prostate cancer model: Sakai, Y., Goodison, S., et al.; World J. Urol. 27, 659 (2009), Abstract
- mTOR inhibitors (rapamycin and its derivatives) and nitrogen containing bisphosphonates: bi-functional compounds for the treatment of bone tumours: B. Ory, et al.; Curr. Med. Chem. 14, 1381 (2007), Review, Abstract
- Rapamycin: an anti-cancer immunosuppressant?: B.K. Law; Crit. Rev. Oncol. Hematol. 56, 47 (2005), Review, Abstract
- NS398 reduces hypoxia-inducible factor (HIF)-1alpha and HIF-1 activity: multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms: Zhong, H., Willard, M., et al.; Int. J. Cancer 112, 585 (2004), Abstract
- Prolactin induces c-Myc expression and cell survival through activation of Src/Akt pathway in lymphoid cells: Domínguez-Cáceres, M. A., García-Martínez, J. M., et al.; Oncogene 23, 7378 (2004), Abstract
- Rapamycin causes poorly reversible inhibition of mTOR and induces p53- independent apoptosis in human rhabdomyosarcoma cells: H. Hosoi, et al.; Cancer Res. 59, 886 (1999), Abstract
- Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability: S. Hashemolhosseini, et al.; J. Biol. Chem. 273, 14424 (1998), Abstract — Full Text
- Rapamycin potentiates dexamethasone-induced apoptosis and inhibits JNK activity in lymphoblastoid cells: T. Ishizuka, et al.; BBRC 230, 386 (1997), Abstract
- Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells: S.M. Metcalfe, et al.; Oncogene 15, 1635 (1997), Abstract
- Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP: J. Choi et al.; Science 273, 239 (1996), Abstract
- The rapamycin and FKBP12 target (RAFT) displays phosphatidylinositol 4-kinase activity: D.M. Sabatini et al.; J. Biol. Chem. 270, 20875 (1995), Abstract
- Control of p70 s6 kinase by kinase activity of FRAP in vivo: E.J. Brown et al.; Nature 377, 441 (1995), Abstract
- Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro: Y. Shi, et al.; Cancer Res. 55, 1982 (1995), Abstract
- Rapamycin, a potent immunosuppressive drug, causes programmed cell death in B lymphoma cells: S. Muthukkumar, et al.; Transplantation 60, 264 (1995), Abstract
- A mammalian protein targeted by G1-arresting rapamycin-receptor complex: E.J. Brown, et al.; Nature 369, 756 (1994), Abstract
- RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin- dependent fashion and is homologous to yeast TORs: D.M. Sabatini, et al.; Cell 78, 35 (1994), Abstract
- Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes: W.G. Morice et al.; J. Biol. Chem. 268, 3734 (1993), Abstract
- Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes: D.C. Fingar et al.; J. Biol. Chem. 268, 3005 (1993), Abstract
- Rapamycin: in vitro profile of a new immunosuppressive macrolide: S.N. Sehgal & C.C. Bansback; Ann. N. Y. Acad. Sci. 685, 58 (1993), Abstract
- Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes: W.G. Morice, et al.; J. Biol. Chem. 268, 22737 (1993), Abstract — Full Text
- Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase: D.J. Price, et al.; Science 257, 973 (1992), Abstract
- Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases: J. Chung et al.; Cell 69, 1227 (1992), Abstract
- FK506 and rapamycin: novel pharmacological probes of the immune response: J.Y. Chang et al.; Trends Pharmacol. Sci. 12, 218 (1991), Abstract
- Inhibition of T and B lymphocyte proliferation by rapamycin: J.E. Kay et al.; Immunology 72, 544 (1991), Abstract
- Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast: J. Heitman et al.; J. Heitman et al. 253, 905 (1991), Abstract
- Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle: C. Vezina, et al.; J. Antibiot. (Tokyo) 28, 721 (1975), Abstract
- Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization: S.N. Sehgal, et al.; J. Antibiot. (Tokyo) 28, 727 (1975), Abstract
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