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RAP (human), (recombinant)

BML-SE552

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RAP functions in ER maturation of lipoprotein receptor family members by acting as an antagonist. It blocks binding of PCSK9 to lipoprotein receptors and of all known ligands (including MMP-9 and apoE) to lipoprotein receptor-related protein 1 (LRP-1). Modulates amyloid deposition in mouse models of Alzheimer’s disease. Reduces endocytosis of prion protein (PrP^c) by neuronal cells.

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Product Details

Alternative Name	LDL receptor associated protein, LRPAP1, LDL receptor-related protein-associated protein 1
Application Notes	Useful tool for binding studies, and testing in vivo and in cell culture.
Formulation	Liquid. In 0.0067M Phosphate, pH 7.4 containing 0.15M sodium chloride.
MW	~39kDa (SDS-PAGE)
Purity	≥90% (SDS-PAGE)
Source	Produced in E. coli.
UniProt ID	P30533

Handling & Storage

Handling	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Low to moderate ethanol exposure reduces astrocyte-induced neuroinflammatory signaling and cognitive decline in presymptomatic APP/PS1 mice: Kang, S., Lee, J., et al.; Sci. Rep. 14, 23989 (2024), Abstract
LRP1 is the cell-surface endocytosis receptor for vaspin in adipocytes: Tindall, C. A., Möhlis, K., et al.; FEBS J. 291, 2134 (2024), Abstract
Regulation of Prostate Androgens by Megalin and 25-hydroxyvitamin D Status: Mechanism for High Prostate Androgens in African American Men: Garcia, J., Krieger, K. D., et al.; Cancer Res. Commun. 3, 371 (2023), Abstract
Elevated prostate androgens in African American men mediated by megalin import of testosterone and 25-hydroxyvitamin D status: Garcia, J., Krieger, K. D., et al.; bioRxiv , (2021)
TNFɑ-induced LDL cholesterol accumulation involve elevated LDLR cell surface levels and SR-B1 downregulation in human arterial endothelial cells: E.U. Okoro; Research Square , (2021)
Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources: A. Schmidts, et al.; J. Immunother. Cancer 8, e000990 (2020), Abstract — Full Text
TNFα-induced LDL cholesterol accumulation involve elevated LDLR cell surface levels and SR-B1 downregulation in human arterial endothelial cells: E.U. Okoro; bioRxiv , (2020)
The dynamic uptake and release of SOD3 from intracellular stores in macrophages modulates the inflammatory response: L. Hu, et al.; Redox Biol. 26, 101268 (2019), Application(s): Treatment of human monocyte-derived macrophages (HMDM) cell cultures, Abstract — Full Text
Lactoferrin induces tropoelastin expression by activating the lipoprotein receptor-related protein 1-mediated phosphatidylinositol 3-kinase/Akt pathway in human dermal fibroblasts: M. Ryu, et al.; Cell Biol. Int. 41, 1325 (2017), Application(s): Treatment of primary normal human dermal fibroblasts in cell culture, Abstract

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RAP (human), (recombinant)

BML-SE552

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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