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RANKL monoclonal antibody (12A668)

ALX-804-243

7 citations

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RANKL monoclonal antibody (12A668) Western blot

Product Details

Alternative Name	ODF, TRANCE, OPGL, TNFSF 11, CD254
Application	IHC (PS), WB
Application Notes	Detects a band of ~35-40kDa by Western blot. Not suitable for flow cytometry.
Clone	12A668
Formulation	Liquid. In PBS containing 0.02% sodium azide.
Host	Mouse
Immunogen	Recombinant mouse RANKL (aa 1-317).
Isotype	IgG1 κ
Purity Detail	Protein G-affinity purified.
Recommendation Dilutions/Conditions	Immunohistochemistry (paraffin sections, 5µg/ml)Western Blot (1-2µg/ml)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Species Reactivity	Human, Mouse
Technical Info / Product Notes	Replacement for ADI-AAM-425, see also ADI-AAM-425AF
UniProt ID	O35235
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Use/Stability	Stable for 6 months when stored at +4°C.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Astaxanthin Protects against Hyperglycemia-Induced Oxidative and Inflammatory Damage to Bone Marrow and to Bone Marrow-Retained Stem Cells and Restores Normal Hematopoiesis in Streptozotocin-Induced Diabetic Mice: G. Bhattarai, et al.; Antioxidants 11, 2321 (2022), Abstract
Astaxanthin Inhibits Diabetes-Triggered Periodontal Destruction, Ameliorates Oxidative Complications in STZ-Injected Mice, and Recovers Nrf2-Dependent Antioxidant System: G. Bhattarai, et al.; Nutrients 13, 3575 (2021), Abstract
Supplemental Ferulic Acid Inhibits Total Body Irradiation-Mediated Bone Marrow Damage, Bone Mass Loss, Stem Cell Senescence, and Hematopoietic Defect in Mice by Enhancing Antioxidant Defense Systems.: Lee, J. C., Kook, S. H., et al.; Antioxidants (Basel) 10, (2021), Application(s): IHC / Reactant(s): Mouse, Abstract
Gamma-glutamyltranspeptidase stimulates receptor activator of nuclear factor-kappaB ligand expression independent of its enzymatic activity and serves as a pathological bone-resorbing factor: S. Niida, et al.; J. Biol. Chem. 279, 5752 (2004), Abstract — Full Text
Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression: R.N. Pearse, et al.; PNAS 98, 11581 (2001), Abstract — Full Text
Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines: P. Fiumara, et al.; Blood 98, 2784 (2001), Abstract — Full Text
Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors: T. Kikuchi, et al.; J. Immunol. 166, 3574 (2001), Abstract — Full Text

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RANKL monoclonal antibody (12A668)

ALX-804-243

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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