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R-(+)-DIOA

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K⁺ channel blocker

Inhibitor of the K⁺/Cl^–-cotransport that does not affect the bumetanide-sensitive Na⁺/K⁺/Cl^–-cotransport system.

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Alternative Name	R-(+)-Butylindazone, (Dihydroindenyl)oxy alkanoic acid
Appearance	White solid.
CAS	81166-47-4
Couple Target	Potassium channel
Couple Type	Blocker
Formula	C₂₀H₂₄Cl₂O₄
MW	399.3
Purity	≥98% (HPLC)
Solubility	Soluble in 100% ethanol or dilute aqueous base; insoluble in water or dilute aqueous acid.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Allodynia and hyperalgesia in diabetic rats are mediated by GABA and depletion of spinal potassium-chloride co-transporters: Jolivalt, C. G., Lee, C. A., et al.; Pain 140, 48 (2008), Abstract
Demonstration of a [K+,Cl-]-cotransport system in human red cells by its sensitivity to [(dihydroindenyl)oxy]alkanoic acids: regulation of cell swelling and distinction from the bumetanide-sensitive [Na+,K+,Cl- ]-cotransport system: R.P. Garay, et al.; Mol. Pharmacol. 33, 696 (1988), Abstract
The significance of the relative effects of loop diuretics and anti-brain edema agents on the Na+,K+,Cl- cotransport system and the Cl-/NaCO3- anion exchanger: R.P. Garay, et al.; Naunyn-Schmiedeberg’s Arch. Pharmacol. 334, 202 (1986), Abstract

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