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(R)-CPP

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NMDA receptor antagonist

Highly potent NMDA receptor antagonist.

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Alternative Name	3-((R)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
Appearance	White crystalline powder.
CAS	126453-07-4
Couple Target	NMDA receptor
Couple Type	Inhibitor, Ligand
Formula	C₈H₁₇N₂O₅P
MW	252.2
Purity	≥97% (HPLC)
Solubility	Soluble in dilute aqueous base or water.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Design and Initial Characterization of a Small Near-Infrared Fluorescent Calcium Indicator: M.E. Matlashov, et al.; Front Cell Dev Biol 10, 880107 (2022), Abstract
Synthesis and NMDA antagonistic properties of the enantiomers of 4-(3-phosphonopropyl)piperazine-2-carboxylic acid (CPP) and of the unsaturated analogue (E)-4-(3-posphonoprop2-enyl)piperazine-2-carboxylic acid (CPP-ene): B. Aebischer, et al.; Helv. Chim. Acta 72, 1043 (1989)
CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]D-AP5 binding sites on brain membranes and anticonvulsant activity: J. Davies, et al.; Brain Res. 382, 169 (1986), Abstract

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