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R-(+)-Baclofen . hydrochloride

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GABA_B receptor agonist

Selective GABA_B receptor agonist. Skeletal muscle relaxant. The more active enantiomer of (±)-Baclofen (Prod. No. BML-EA128).

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Alternative Name	R-(+)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid . HCl, R-(+)-4-Amino-3-(4-chlorophenyl)butanoic acid . HCl
Appearance	White to off-white solid.
CAS	63701-55-3
Couple Target	GABA receptor
Couple Type	Activator, Ligand
Formula	C₁₀H₁₂ClNO₂ . HCl
MI	14: 937
MW	213.7 . 36.5
Purity	≥98% (HPLC)
RTECS	MW5084350
Solubility	Soluble in water, dilute aqueous base or DMSO.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A novel cause of intrathecal baclofen overdosage: lessons to be learnt: C. Dalton, et al.; Clin. Rehabil. 22, 188 (2008), Abstract
Skeletal muscle relaxants: S. See & R. Ginzburg; Pharmacotherapy 28, 207 (2008), Abstract
Effects of GABA(B) receptor ligands in animal tests of depression and anxiety: M. Frankowska, et al.; Pharmacol. Rep. 59, 645 (2007), Abstract
Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat: Y.G. Hong & J.L. Henry; Eur. J. Pharmacol. 196, 267 (1991), Abstract
Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations: E. Falch, et al.; J. Neurochem. 47, 898 (1986), Abstract
3-(p-Chlorophenyl)-4-aminobutanoic acid–resolution into enantiomers and pharmacological activity: B. Witczuk, et al.; Pol. J. Pharmacol. Pharm. 32, 187 (1980), Abstract

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