R-848

ALX-420-038

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Ligand for TLR7 and TLR8

Highly pure and selective ligand for TLR7 and TLR8
Highly cited

R-848 is a selective ligand for Toll-like receptor 7 (TLR7) in mouse and for TLR7 and TLR8 in human. R-848 displays potent antitumor, proinflammatory, and anti-viral properties. R-848 stimulates antibody secretion, cytokine production (e.g. IL-6, IL-12, and IFNg), protection from apoptosis, and CD80 upregulation.

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Product Details

Alternative Name	4-Amino-2-(ethoxymethyl)-a,a-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol, S 28463, Resiquimod
Appearance	White to off-white solid.
CAS	144875-48-9
Couple Target	TLR, TLR7, TLR8
Couple Type	Ligand
Endotoxin Content	Endotoxin-free
Formula	C₁₇H₂₂N₄O₂
Identity	Identity determined by MS, 1H-NMR, and 13C-NMR.
MW	314.4
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO, 100% methanol, 5% methanol in dichloromethane; poorly soluble in acetonitrile or ethyl acetate.
Source	Synthetic

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Altered baseline immunological state and impaired immune response to SARS-CoV-2 mRNA vaccination in lung transplant recipients: Hu, M., Oliveira, A. P. B. N., et al.; Cell Rep. Med. 6, 102050 (2025), Abstract
The immunoglobulin M-degrading enzyme of Streptococcus suis (IdeSsuis) leads to long-lasting inhibition of the activation of porcine IgM-secreting B cells: Breitfelder, A. K., Schrödl, W., et al.; Vet. Res. 55, 114 (2024), Abstract
An Analysis of Linker-Dependent Effects on the APC Activation and In Vivo Immunogenicity of an R848-Conjugated Influenza Vaccine: K.F. Crofts, et al.; Vaccines 11, 1261 (2023), Abstract
CCL5-producing migratory dendritic cells guide CCR5+ monocytes into the draining lymph nodes: K. Rawat, et al.; J. Exp. Med. 220, e20222129 (2023), Abstract
Immune monitoring of SARS-CoV-2-specific T cell and B cell responses in patients with multiple sclerosis treated with ocrelizumab: Groß-Albenhausen, E., Weier, A., et al.; Front. Immunol. 14, 1254128 (2023), Abstract
Inhibition of IL-12 heterodimers impairs TLR9-mediated prevention of early mouse plasmacytoma cell growth: Mandour, M. F., Soe, P. P., et al.; Front. Med. (Lausanne) 9, 1057252 (2023), Abstract
TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung antiviral immunity: Jackson, W. D., Giacomassi, C., et al.; Elife 12, (2023), Abstract
LL-37 as a Powerful Molecular Tool for Boosting the Performance of Ex Vivo-Produced Human Dendritic Cells for Cancer Immunotherapy: D. Stakheev, et al.; Pharmaceutics 14, 2747 (2022), Abstract
RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice: X. Zhong, et al.; PNAS 119, e2200128119 (2022), Abstract
The mycotoxin Beauvericin exhibits immunostimulatory effects on dendritic cells via activating the TLR4 signaling pathway: X. Yang, et al.; Front. Immunol. 13, 856230 (2022), Abstract — Full Text