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Quercetin . dihydrate

ALX-385-001

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Antioxidant flavonoid

Antioxidant flavonoid. Inhibitor of mitochondrial ATPase, cAMP- and cGMP-phosphodiesterases. Inhibitor of protein tyrosine kinases and protein kinase C (PKC). Induces apoptosis. Blocks cells at the G0/G1 interface. Activator of human deacetylase SIRT1. Reversible inhibitor of fatty acid synthase (FAS). Inhibits the production of the inflammatory mediators nitric oxide (NO), TNF-α and IL-12 in activated macrophages.Induces gastric relaxation in mouse stomach, mainly by suppressing Ca²⁺ influx through voltage-dependent calcium channels.

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Product Details

Alternative Name	3,3′,4′,5,7-Pentahydroxyflavone . 2H2O
Appearance	Yellow powder with a green or brown cast.
CAS	6151-25-3
Couple Target	ATPase, Fatty acid synthase, PDE, PKC, SIRT, SIRT1
Couple Type	Activator, Inhibitor
Formula	C₁₅H₁₀O₇ . 2H₂O
MI	14: 8034
MW	302.2 . 36.0
Purity	≥95% (HPLC)
RTECS	LK8950000
Solubility	Soluble in 100% ethanol or 1M sodium hydroxide; almost insoluble in water.
Source	Isolated from Sophora japonica L.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Dietary Quercetin Attenuates Adipose Tissue Expansion and Inflammation and Alters Adipocyte Morphology in a Tissue-Specific Manner: Forney, L. A., Lenard, N. R., et al.; Int. J. Mol. Sci. 19, (2018), Abstract
Quercetin and Quercetin-Rich Red Onion Extract Alter Pgc-1α Promoter Methylation and Splice Variant Expression: P.P. Devarshi, et al.; PPAR Res. 2017, 3235693 (2017), Abstract — Full Text
In vivo effects of dietary quercetin and quercetin-rich red onion extract on skeletal muscle mitochondria, metabolism, and insulin sensitivity: Henagan, T. M., Cefalu, W. T., et al.; Genes Nutr. 10, 451 (2015), Abstract
Quercetin Inhibits Pacemaker Potentials via Nitric Oxide/cGMP-Dependent Activation and TRPM7/ANO1 Channels in Cultured Interstitial Cells of Cajal from Mouse Small Intestine: H. Gim, et al.; Cell. Physiol. Biochem. 35, 2422 (2015), Application(s): Cell Culture, Abstract — Full Text
A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4: Krishna, S. N., Luan, C. H., et al.; PLoS One 8, e81504 (2013), Abstract
Ethanolic extract of Brazilian green propolis sensitizes prostate cancer cells to TRAIL-induced apoptosis: Szliszka, E., Zydowicz, G., et al.; Int. J. Oncol. 38, 941 (2011), Abstract
Gastric relaxation induced by apigenin and quercetin: Analysis of the mechanism of action: A. Rotondo, et al.; Life Sciences 85, 85 (2009), Abstract
Onions: a source of unique dietary flavonoids: R. Slimestad, et al.; J. Agric. Food Chem. 55, 10067 (2007), Abstract
Pharmacological inhibitors of Fatty Acid Synthase (FASN)–catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?: R. Lupu & J. A. Menendez; Curr. Pharm. Biotechnol. 7, 483 (2006), (Review), Abstract
Inhibitory effects of the flavonoids isolated from Waltheria indica on the production of NO, TNF-alpha and IL-12 in activated macrophages: Y.K. Rao, et al.; Biol. Pharm. Bull. 28, 912 (2005), Abstract

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Quercetin . dihydrate

ALX-385-001

Product Details

Handling & Storage

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