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PDE inhibitor

Selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III, IC₅₀=0.6µM).

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Alternative Name	Ro 13-6438, (R)-6-Chloro-1,5-dihydro-3-methyl- imidazo[2,1-b]quinazolin-2-one
Appearance	White to off-white solid.
CAS	70018-51-8
Couple Target	PDE
Couple Type	Inhibitor
Formula	C₁₁H₁₀ClN₃O
MW	235.7
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (3mg/ml) or 100% ethanol (1mg/ml).
Technical Info / Product Notes	Note: Product is not sterile.

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

FGF1 and insulin control lipolysis by convergent pathways: Sancar, G., Liu, S., et al.; Cell Metab. 34, 171 (2022), Abstract
Studies on the mechanism of positive inotropic activity of Ro 13-6438, a structurally novel cardiotonic agent with vasodilating properties: M. Holck, et al.; J. Cardiovasc. Pharmacol. 6, 520 (1984), Abstract

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