Home Shop Pyrrolidinedithiocarbamic acid . ammonium salt

Pyrrolidinedithiocarbamic acid . ammonium salt

ALX-400-002

14 citations

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Inhibitor of NF-κB activation

Inhibitor of NF-κB activation (induced by either PMA or TNF-α) in various cell types.

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Product Details

Alternative Name	Ammoniumpyrrolidinedithiocarbamate, Ammoniumtetramethylenedithiocarbamate
Appearance	White to-off white solid.
CAS	5108-96-3
Couple Target	NF-kappaB
Couple Type	Inhibitor
Formula	C₅H₈NS₂ . NH₄
MW	146.3 . 18.0
Purity	≥98% (HPLC)
Solubility	Soluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation: S. Hamarsheh, et al.; Nat. Commun. 11, 1659 (2020), Abstract — Full Text
Visfatin Promotes Monocyte Adhesion by Upregulating ICAM-1 and VCAM-1 Expression in Endothelial Cells via Activation of p38-PI3K-Akt Signaling and Subsequent ROS Production and IKK/NF-κB Activation: Y.T. Lin, et al.; Cell. Physiol. Biochem. 52, 1398 (2019), Abstract — Full Text
Interaction with macrophages attenuates Equine Fibroblast-Like Synoviocyte ADAMTS5 (aggrecanase-2) gene expression following inflammatory stimulation: R.E. Morgan, et al.; J. Orthop. Res. 36, 2178 (2018), Abstract
Pyrrolidine dithiocarbamate inhibits TNF-alpha-dependent activation of NF-kappaB by increasing intracellular copper level in human aortic smooth muscle cells: A. Iseki, et al.; Biochem. Biophys. Res. Commun. 276, 88 (2000), Abstract
Zinc is required in pyrrolidine dithiocarbamate inhibition of NF-kappaB activation: C.H. Kim, et al.; FEBS Lett. 449, 28 (1999), Abstract
Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate prevents In vivo expression of proinflammatory genes: S.F. Liu, et al.; Circulation 100, 1330 (1999), Abstract
Dual activity of pyrrolidine dithiocarbamate on kappaB-dependent gene expression in U937 cells: II. Regulation by tumour necrosis factor-alpha: K. Watanabe, et al.; Cell Signal. 11, 371 (1999), Abstract
Dual activity of pyrrolidine dithiocarbamate on kappaB-dependent gene expression in U937 cells: I. Regulation by the phorbol ester TPA: K. Watanabe, et al.; Cell Signal. 11, 479 (1999), Abstract
In vivo inhibition of nuclear factor-kappa B activation prevents inducible nitric oxide synthase expression and systemic hypotension in a rat model of septic shock: S.F. Liu, et al.; J. Immunol. 159, 3976 (1997), Abstract
In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation: T.S. Blackwell, et al.; Immunol. 157, 1630 (1996), Abstract

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Pyrrolidinedithiocarbamic acid . ammonium salt

ALX-400-002

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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