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Pyripyropene A

ALX-350-134

15 citations

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ACAT2 inhibitor

Highly specific inhibitor of acyl-coenzyme A:cholesterol acetyltransferase 2 (ACAT2).

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Product Details

Alternative Name	(+)-Pyripyropene A, PPPA
Appearance	White to brown powder.
CAS	147444-03-9
Couple Target	ACAT
Couple Type	Inhibitor
Formula	C₃₁H₃₇NO₁₀
MW	583.6
Purity	≥85% (HPLC)
Solubility	Soluble in DMSO,chloroform, methanol or ethyl acetate; insoluble in water or hexane.
Source	Isolated from Aspergillus fumigatus FO-1289.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Sterol O-Acyltransferase 2 Contributes to the Yolk Cholesterol Trafficking during Zebrafish Embryogenesis: Chang, N. Y., Chan, Y. J., et al.; PLoS One 11, e0167644 (2016), Abstract
Potential therapeutics for obesity and atherosclerosis: inhibitors of neutral lipid metabolism from microorganisms: H. Tomoda & S. Omura; Pharmacol. Ther. 115, 375 (2007), Abstract
Exploiting PdII and TiIII chemistry to obtain gamma-dioxygenated terpenoids: synthesis of rostratone and novel approaches to aphidicolin and pyripyropene A: J. Justicia, et al.; J. Org. Chem. 70, 8265 (2005), Abstract
Total synthesis of alpha-pyrone meroterpenoids, novel bioactive microbial metabolites: T. Sunazuka and S. Omura; Chem. Rev. 105, 4559 (2005), Abstract
Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay: individual ACAT uniqueness: A.T. Lada, et al.; J. Lipid Res. 45, 378 (2004), Abstract — Full Text
ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver: P. Parini, et al.; Circulation 110, 2017 (2004), Abstract — Full Text
Mass-production of human ACAT-1 and ACAT-2 to screen isoform-specific inhibitor: a different substrate specificity and inhibitory regulation: K.H. Cho, et al.; BBRC 309, 864 (2003), Abstract
Meroterpenoids with various biological activities produced by fungi: K. Shiomi, et al.; Pure Appl. Chem. 71, 1059 (1999), Full Text
A formal synthesis of (+)-pyripyropene A using a biomimetic epoxy-olefin cyclisation: effect of epoxy alcohol/ether on cyclisation efficiency: V.K. Aggarwal, et al.; J. Chem. Soc. , 3315 (1999), Full Text
Biosynthesis of Pyripyropene A: H. Tomoda, et al.; J. Org. Chem. 61, 882 (1996)

Last modified: May 29, 2024

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Pyripyropene A

ALX-350-134

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