Pyocyanin

ENZ-53001

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ROS inducer

Cytotoxic pigment secreted by Pseudomonas aeruginosa, which frequently infects the lungs of immuno-suppressed patients, as well as those with cystic fibrosis. Pyocyanin toxicity results from its ability to undergo reduction by NAD(P)H and subsequent generation of superoxide and H₂O₂ directly in the lungs.

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Pyocyanin fig — **Figure:** Pyocyanin is reduced by NAD(P)H and generates superoxide and H₂O₂.

Product Details

Alternative Name	Sanasin, 1-hydroxy-N-methylphenazine
CAS	85-66-5
Couple Target	ROS
Couple Type	Dye
Formula	C₁₃H₁₀N₂O
Formulation	Lyophilized.
MW	210.2
Purity	≥98% (HPLC)
Quantity	1 μmol
Reconstitution	Reconstitute the contents of the vial in 100μl solvent to yield a 10mM stock solution.
Solubility	Soluble in DMSO or dimethyl formamide.
Technical Info / Product Notes	Pyocyanin is a member of the CELLESTIAL^® product line, reagents and assay kits comprising fluorescent molecular probes that have been extensively benchmarked for live cell analysis applications. CELLESTIAL^® reagents and kits are optimal for use in demanding imaging applications, such as confocal microscopy, flow cytometry and HCS, where consistency and reproducibility are required.

Handling & Storage

Use/Stability	Stable for at least 1 year after receipt when stored at -80°C.
Handling	Avoid freeze/thaw cycles.
Short Term Storage	-20°C
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Higher sensitivity of female cells to ethanol: methylation of DNA lowers Cyp2e1, generating more ROS: Penaloza, C. G., Cruz, M., et al.; Cell Commun. Signal. 18, 111 (2020), Abstract
Paper-based sensors for rapid detection of virulence factor produced by Pseudomonas aeruginosa: F.A. Alatraktchi, et al.; PLoS One 13, e0194157 (2018), Abstract — Full Text
Functional pseudogenes inhibit the superoxide production: W. Xu, et al.; Precision Medicine 2, e745 (2015), Application(s): Cell Culture, Fluorescence Microscopy, Full Text
ROS production as a common mechanism of ENaC regulation by EGF, insulin, and IGF-1: Ilatovskaya, D. V., Pavlov, T. S., et al.; Am. J. Physiol. Cell Physiol. 304, C102 (2013), Abstract
Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa.: S.M. Bianchi, et al.; Am. J. Respir. Crit. Care Med. 177, 35 (2008), Abstract
Pyocyanin production by Pseudomonas aeruginosa induces neutrophil apoptosis and impairs neutrophil-mediated host defenses in vivo.: L. Allen, et al.; J. Immunol. 174, 3643 (2005), Abstract

Last modified: May 29, 2024

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Pyocyanin

ENZ-53001

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