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Puromycin Aminonucleoside

BML-A260

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Puromycin analog that does not inhibit protein synthesis

A puromycin analog which does not inhibit protein synthesis or induce apoptosis. It is a glomerular epithelial cell toxin which may be used to induce nephropathy in laboratory animals.

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Product Details

Alternative Name	3′-Amino-3′-Deoxy-N,N-dimethyladenosine
Appearance	White solid.
CAS	58-60-6
Formula	C₁₂H₁₆N₆O₃
MW	294.3
MeltingPoint	222-223°C
Purity	≥98% (TLC)
Solubility	Soluble in water (10mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Downregulation of the phosphatase PHLPP1 contributes to NNK-induced malignant transformation of human bronchial epithelial cells (HBECs): Liu, X., Huang, S., et al.; J. Biol. Chem. 301, 108221 (2025), Abstract
Autophagy-mediated Mir6981 degradation exhibits CDKN1B promotion of PHLPP1 protein translation: Peng, M., Wang, J., et al.; Autophagy 15, 1523 (2019), Abstract
Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells: Huang, H., Zhu, J., et al.; Autophagy 12, 1687 (2016), Abstract
Puromycin aminonucleoside suppresses integrin expression in cultured glomerular epithelial cells: U. Krishnamurti et al.; J. Am. Soc. Nephrol. 12, 758 (2001), Abstract
Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis: S.C. Chow et al.; Exp Cell Res 216, 1995 (1995), Abstract
Dietary vitamin E supplementation ameliorates renal injury in chronic puromycin aminonucleoside nephropathy: H. Trachtman et al.; J. Am. Soc. Nephrol. 5, 1811 (1995), Abstract

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Puromycin Aminonucleoside

BML-A260

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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