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Protein synthesis inhibitor
Inhibits protein synthesis. Inhibits translation by causing premature release of nascent polypeptide. Induces apoptosis.
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Product Details
| Alternative Name |
3′-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-adenosine . 2HCl, 3′-(α-Amino-p-methoxy-hydrocinnamamido-3′-deoxy-N,N-dimethyl-adenosine . 2HCl |
|---|---|
| Appearance |
White to off-white solid. |
| CAS |
58-58-2 |
| Formula |
C22H29N7O5 . 2HCl |
| MI |
14: 7943 |
| MW |
544.4 |
| Purity |
≥98% (HPLC, TLC) |
| RTECS |
AU7355000 |
| Solubility |
Soluble in water (50mg/ml). |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
|---|---|
| Handling |
Protect from moisture. |
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Inhibition of DNMT3B and PI3K/AKT/mTOR and ERK Pathways as a Novel Mechanism of Volasertib on Hypomethylating Agent-Resistant Cells: E.J. Choi, et al.; Biomol. Ther. 31, 319 (2023), Abstract
- HDAC8 Deacetylates HIF-1α and Enhances Its Protein Stability to Promote Tumor Growth and Migration in Melanoma: J.Y. Kim, et al.; Cancers (Basel) 15, 1123 (2023), Abstract
- ER-trafficking triggers NRF1 ubiquitination to promote its proteolytic activation: Chavarria, C., Zaffalon, L., et al.; iScience 26, 107777 (2023), Abstract
- Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN: Ke, P. Y., Chang, C. W., et al.; Cells 11, (2022), Abstract
- Targeting regulation of ATP synthase 5 alpha/beta dimerization alleviates senescence: Lee, Y. H., Choi, D., et al.; Aging (Albany NY) 14, 678 (2022), Abstract
- Inhibition of mTORC1 differentially affects ribosome biogenesis in rat soleus muscle at the early and later stages of hindlimb unloading: S.V. Rozhkov, et al.; Arch. Biochem. Biophys. 730, 109411 (2022), Abstract
- Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy: Harbauer, A. B., Hees, J. T., et al.; Neuron 110, 1516 (2022), Abstract
- LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance: S. Michalek, et al.; EMBO Rep. 23, e54195 (2022), Abstract
- Effect of Clinically Used Microtubule Targeting Drugs on Viral Infection and Transport Function: M.Á. Oliva, et al.; Int. J. Mol. Sci. 23, 3448 (2022), Abstract
- The Role of Glycogen Synthase Kinase-3 in the Regulation of Ribosome Biogenesis in Rat Soleus Muscle under Disuse Conditions: S.V. Rozhkov, et al.; Int. J. Mol. Sci. 23, 2751 (2022), Abstract
- Development of a potent high-affinity human therapeutic antibody via novel application of recombination signal sequence-based affinity maturation: A. Kielczewska, et al.; J. Biol. Chem. 298, 101533 (2022), Abstract
- NFAT5 promotes oral squamous cell carcinoma progression in a hyperosmotic environment: S. Yoshimoto, et al.; Lab. Invest. 101, 38 (2021), Abstract — Full Text
- Cytokinin-induced protein synthesis suppresses growth and osmotic stress tolerance: S.S. Karunadasa, et al.; New Phytol. 227, 50 (2020), Application(s): Treatment of A. thaliana seedlings, Abstract
- Transcription Factor EB Activation Rescues Advanced αB-Crystallin Mutation-Induced Cardiomyopathy by Normalizing Desmin Localization: Ma, X., Mani, K., et al.; J. Am. Heart Assoc. 8, e010866 (2019), Abstract
- Mice lacking L-12/15-lipoxygenase show increased mortality during kindling despite demonstrating resistance to epileptogenesis: M.A. Kanzler, et al.; Epilepsia Open 3, 255 (2018), Application(s): Cell Culture, Abstract — Full Text
- Inhibition of Membrane-Bound BAFF by the Anti-BAFF Antibody Belimumab: C. Kowalczyk-Quintas, et al.; Front. Immunol. 9, 2698 (2018), Application(s): HEK293T cell selection after transfection, Abstract — Full Text
- Redundant and Antagonistic Roles of XTP3B and OS9 in Decoding Glycan and Non-glycan Degrons in ER-Associated Degradation: van der Goot, A. T., Pearce, M. M. P., et al.; Mol. Cell 70, 516 (2018), Abstract
- Size control in mammalian cells involves modulation of both growth rate and cell cycle duration: Cadart, C., Monnier, S., et al.; Nat. Commun. 9, 3275 (2018), Abstract
- Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation: C. Zhao, et al.; Oxid. Med. Cell. Longev. 2016, 2927131 (2016), Application(s): Retrovirus Production and Transduction, Abstract — Full Text
- Changes in O-GlcNAc homeostasis activate the p53 pathway in ovarian cancer cells: R.M. de Queiroz, et al.; J. Biol. Chem. 291, 18897 (2016), Application(s): Cell culture, human cell lines, Abstract
- Lactobacillus brevis T2102 suppresses the growth of colorectal cancer cells by activating SIRT1: G. Harada, et al.; J. Functional Foods 23, 444 (2016), Application(s): Cell culture
- Mapping growth-factor-modulated Akt signaling dynamics: Gross, S. M., Rotwein, P., et al.; J. Cell Sci. 129, 2052 (2016), Abstract
- Expression of the ALS-causing variant hSOD1G93A leads to an impaired integrity and altered regulation of claudin-5 expression in an in vitro blood-spinal cord barrier model: S. Meister, et al.; J. Cereb. Blood Flow Metab. 35, 1112 (2015), Application(s): Cell Culture, Abstract
- Rapid recombinant protein production from piggyBac transposon-mediated stable CHO cell pools: S. Balasubramanian, et al.; J. Biotechnol. 200, 61 (2015), Application(s): Cell Culture, Abstract
- Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells: Bilir, B., Kucuk, O., et al.; J. Transl. Med. 11, 280 (2013), Abstract
- Inhibition of puromycin-induced apoptosis in breast cancer cells by IGF-I occurs simultaneously with increased protein synthesis: G. Soderlund, et al.; Neoplasma 51, 1 (2004), Abstract
- Puromycin Aminonucleoside Induces Glomerular Epithelial Cell Apoptosis: V. Sanwal, et al.; Exp. Mol. Pathol. 70, 54 (2001), Abstract
- Increased Apoptosis in Acute Puromycin Aminonucleoside Nephrosis: L. Fernandez, et al.; Exp. Nephrol. 9, 99 (2001), Abstract
- Cell proliferation and apoptosis of the glomerular epithelial cells in rats with puromycin aminonucleoside nephrosis: H. Shiiki, et al.; Pathobiology 66, 221 (1998), Abstract
- Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis: S.C. Chow, et al.; Exp. Cell Res. 216, 149 (1995), Abstract
- Puromycin-sensitive aminopeptidase. Sequence analysis, expression, and functional characterization: D.B. Constam, et al.; J. Biol. Chem. 270, 26931 (1995), Abstract — Full Text
- Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis: S.H. Kaufmann, et al.; Cancer Res. 53, 3976 (1993), Abstract
- Unexpected cytokinetic effects induced by puromycin include a G2- arrest, a metaphase-mitotic-arrest, and apoptosis: A.N. Davidoff & B.V. Mendelow; Leuk. Res. 16, 1077 (1992), Abstract
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