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Purmorphamine

ALX-420-045

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Smoothened activator

Cell permeable purine compound. Induces osteoblast differentiation. Agonist of smoothened by activation of the Hedgehog (Hh) pathway. Also shown to induce transdifferentiation in pre-adipocytes and myoblasts. Binds to and activates 7-transmembrane receptor of Hh.

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Product Details

Alternative Name	2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine
Appearance	Off-white to beige solid.
CAS	483367-10-8
Couple Target	Smoothened
Couple Type	Activator
Formula	C₃₁H₃₂N₆O₂
MW	520.6
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (10mM).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions are stable for up to 3 months when stored at -20°C.
Handling	Protect from light. After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

α-Synuclein Pathology Spreads in a Midbrain-Hindbrain Assembloid Model: Gomez-Giro, G., Frangenberg, D., et al.; Adv. Sci. (Weinh.) 12, e2409040 (2025), Abstract
Omics data integration suggests a potential idiopathic Parkinson’s disease signature: A. Zagare, et al.; Commun. Biol. 6, 1179 (2023), Abstract
A human stem cell-derived test system for agents modifying neuronal N-methyl-d-aspartate-type glutamate receptor Ca2+-signalling: S. Klima, et al.; Arch. Toxicol. 95, 1703 (2021), Abstract
A directional 3D neurite outgrowth model for studying motor axon biology and disease: Spijkers, X. M., Pasteuning-Vuhman, S., et al.; Sci. Rep. 11, 2080 (2021), Abstract
Parkinson’s disease phenotypes in patient specific brain organoids are improved by HP-β-CD treatment: Jarazo, J., Barmpa, K., et al.; bioRxiv , (2019)
Millifluidic culture improves human midbrain organoid vitality and differentiation: E. Berger, et al.; Lab Chip 18, 3172 (2018), Abstract — Full Text
Lung Fibroblasts Share Mesenchymal Stem Cell Features Which Are Altered in Chronic Obstructive Pulmonary Disease via the Overactivation of the Hedgehog Signaling Pathway: F. Figeac, et al.; PLoS One 10, e0121579 (2015), Application(s): Cell Culture, Abstract — Full Text
Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein: M. Ehrlich, et al.; Stem Cell Reports 5, 83 (2015), Application(s): Cell Culture, Abstract — Full Text
Hedgehog pathway signaling regulates human colon carcinoma HT-29 epithelial cell line apoptosis and cytokine secretion: Yoshimoto, A. N., Bernardazzi, C., et al.; PLoS One 7, e45332 (2012), Abstract
Purmorphamine activates the Hedgehog pathway by targeting Smoothened: S. Sinha & J.K. Chen; Nat. Chem. Biol. 2, 29 (2006), Abstract

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Purmorphamine

ALX-420-045

Product Details

Handling & Storage

Resources

Metabolism

Cellular Therapy

Cardiovascular Research

Drug Discovery

AMPIVIEW® RNA Probes

Immuno-Oncology

AMPIGENE® PCR Solutions

Bioprocess

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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