Home Shop Purmorphamine

Purmorphamine

ALX-420-045

Datasheet
Manual
SDS
CofA

Already have an account?

ALX-420-045-M001 — 1 mg

$175.00

Purmorphamine quantity
ALX-420-045-M005 — 5 mg

$245.00

Purmorphamine quantity
ALX-420-045-M025 — 25 mg

$810.00

Purmorphamine quantity

Smoothened activator

Cell permeable purine compound. Induces osteoblast differentiation. Agonist of smoothened by activation of the Hedgehog (Hh) pathway. Also shown to induce transdifferentiation in pre-adipocytes and myoblasts. Binds to and activates 7-transmembrane receptor of Hh.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Product Details

Alternative Name	2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine
Appearance	Off-white to beige solid.
CAS	483367-10-8
Couple Target	Smoothened
Couple Type	Activator
Formula	C₃₁H₃₂N₆O₂
MW	520.6
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (10mM).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions are stable for up to 3 months when stored at -20°C.
Handling	Protect from light. After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

α-Synuclein Pathology Spreads in a Midbrain-Hindbrain Assembloid Model: Gomez-Giro, G., Frangenberg, D., et al.; Adv. Sci. (Weinh.) 12, e2409040 (2025), Abstract
Omics data integration suggests a potential idiopathic Parkinson’s disease signature: A. Zagare, et al.; Commun. Biol. 6, 1179 (2023), Abstract
A human stem cell-derived test system for agents modifying neuronal N-methyl-d-aspartate-type glutamate receptor Ca2+-signalling: S. Klima, et al.; Arch. Toxicol. 95, 1703 (2021), Abstract
A directional 3D neurite outgrowth model for studying motor axon biology and disease: Spijkers, X. M., Pasteuning-Vuhman, S., et al.; Sci. Rep. 11, 2080 (2021), Abstract
Parkinson’s disease phenotypes in patient specific brain organoids are improved by HP-β-CD treatment: Jarazo, J., Barmpa, K., et al.; bioRxiv , (2019)
Millifluidic culture improves human midbrain organoid vitality and differentiation: E. Berger, et al.; Lab Chip 18, 3172 (2018), Abstract — Full Text
Lung Fibroblasts Share Mesenchymal Stem Cell Features Which Are Altered in Chronic Obstructive Pulmonary Disease via the Overactivation of the Hedgehog Signaling Pathway: F. Figeac, et al.; PLoS One 10, e0121579 (2015), Application(s): Cell Culture, Abstract — Full Text
Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein: M. Ehrlich, et al.; Stem Cell Reports 5, 83 (2015), Application(s): Cell Culture, Abstract — Full Text
Hedgehog pathway signaling regulates human colon carcinoma HT-29 epithelial cell line apoptosis and cytokine secretion: Yoshimoto, A. N., Bernardazzi, C., et al.; PLoS One 7, e45332 (2012), Abstract
Purmorphamine activates the Hedgehog pathway by targeting Smoothened: S. Sinha & J.K. Chen; Nat. Chem. Biol. 2, 29 (2006), Abstract

Resources

Brochures

Metabolism

Download Resource

Brochures

Cellular Therapy

Download Resource

Brochures

Cardiovascular Research

Download Resource

Brochures

Drug Discovery

Download Resource

Brochures

AMPIVIEW® RNA Probes

Download Resource

Brochures

Immuno-Oncology

Download Resource

Brochures

AMPIGENE® PCR Solutions

Download Resource

Brochures

Bioprocess

Download Resource

Related Products

(+)-Egenine

ALX-350-362

6 citations

Alternative Name	6-(6-Methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-6,8-dihydrofuro[3,4-E][1,3]benzodioxol-8-ol, (+)-Decumbensine
CAS	6883-44-9
Purity	≥98% (HPLC)

(+)-Himbacine

ALX-550-061

Muscarinic acetylcholine receptor antagonist

8 citations

Alternative Name	(3S,3aR,4R,4aS,8aR,9aS)-4-[(1E)-2-[(2R,6S)-1,6-Dimethyl-2-piperdinyl]ethenyl]decahydro-3-methyl-naphtho[2,3-c]furan-1(3H)-one
CAS	6879-74-9
Couple Type	Inhibitor
Purity	≥98%

(+)-Indolactam V

ALX-420-010

CAS	90365-56-3
Purity	≥95% (1H-NMR)

(+/-)Cyanopindolol hemifumarate

BML-AR101

Adrenergic receptor and serotonin receptor antagonist

5 citations

CAS	69906-85-0
Couple Type	Ligand
Purity	≥99% (TLC)

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Datasheet

Certificate of Analysis

Please enter the lot number as featured on the product label

Lot No. :

SDS

Enzo Life Science provides GHS Compliant SDS

If your language is not available please fill out the SDS request form

Your Cart

Your Cart

Purmorphamine

ALX-420-045

Product Details

Handling & Storage

Resources

Metabolism

Cellular Therapy

Cardiovascular Research

Drug Discovery

AMPIVIEW® RNA Probes

Immuno-Oncology

AMPIGENE® PCR Solutions

Bioprocess

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

Change Country

Tell us about You

Tell us about your paper

Tell us about You

Tell us about your project