Puerarin

ALX-350-249

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5-HT2c inhibitor

Biologically active isoflavone. Affects serotonin levels and platelet aggregation in blood cells. 5-HT2c antagonist. Antibacterial. Displays cardioprotective effects. Induces apoptosis.

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Product Details

Alternative Name	8-(β-D-Glucopyranosyl-7-hydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one, NPI-031G
Appearance	White to off-white powder.
CAS	3681-99-0
Couple Target	Serotonin receptor
Couple Type	Inhibitor, Ligand
Formula	C₂₁H₂₀O₉
MW	416.4
Purity	≥98% (HPLC)
RTECS	UO5216000
Solubility	Soluble in methanol.
Source	Isolated from Kudzu root.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Puerarin inhibits proliferation and induces apoptosis in human glioblastoma cell lines: J. Yang, et al.; Int. J. Clin. Exp. Med. 8, 10132 (2015), Application(s): Effect of puerarin on human glioblastoma cells, Abstract — Full Text
Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin: 574, 179 (2007): Q. Gao, et al.; Eur. J. Pharmacol. 574, 179 (2007), Abstract
Induction of apoptosis by puerarin in colon cancer HT-29 cells: Z. Yu & W. Li; Cancer Lett. 238, 53 (2006), Abstract
Puerarin reduces increased c-fos, c-jun, and type IV collagen expression caused by high glucose in glomerular mesangial cells: C.P. Mao & Z.L. Gu; Acta Pharmacol. Sin. 26, 982 (2005), Abstract
Contrasting effects of puerarin and daidzin on glucose homeostasis in mice: E. Meezan, et al.; J. Agric. Food Chem. 53, 8760 (2005), Abstract
NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists: D.H. Overstreet, et al.; Pharmacol. Biochem. Behav. 75, 619 (2003), Abstract
Metabolism of puerarin and daidzin by human intestinal bacteria and their relation to in vitro cytotoxicity: D.H. Kim, et al.; Biol. Pharm. Bull. 21, 628 (1998), Abstract
Daidzin and its antidipsotropic analogs inhibit serotonin and dopamine metabolism in isolated mitochondria: W.M. Keung & B.L. Vallee; PNAS 95, 2198 (1998), Abstract

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Puerarin

ALX-350-249

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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