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PTP1B (human), (recombinant)

BML-SE332

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PTP1B is the ubiquitous, prototypical nontransmembrane PTP originally identified in human placenta.

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PTP1B (human), (recombinant) SDS-PAGE — SDS-PAGE Analysis: Lane 1: MW Marker, Lane 2: 1 µg, Lane 3: 2 µg, Lane 4: 5 µg PTP1B. The higher molecular weight bands are BSA included for stability in storage buffer.

PTP1B (human), (recombinant) Western Blot — Western Blot analysis of PTP1B (human), (recombinant) (Prod. No. BML-SE332): Lane 1: MW Marker, Lane 2: 100ng of PTP1B (human), (recombinant) probed with Anti-6X His tag® antibody.

Product Details

Alternative Name	Protein tyrosine phosphatase 1B
Application Notes	Useful for the study of tyrosine phosphatase kinetics, substrate specificity and for screening inhibitors.
Formulation	Liquid. In 50mM HEPES, pH7.2, containing 1mM EDTA, 5mM DTT, and 0.05% NP-40.
MW	~37.4kDa
Purity	≥95% (SDS-PAGE)
Purity Detail	Purified by multi-step chromatography.
Source	Produced in E. coli. Human PTP1B (protein tyrosine phosphatase 1B) (aa 1-322).
Specific Activity	≥20 µmol/min/mg at 30°C using 0.15mM of phosphopeptide substrate based on EGFR residues 988-998 (Prod. No. BML-P323) in 50mM HEPES, pH 7.2, 1mM EDTA, 1mM DTT, 0.05% NP-40, and 0.2µg/µl BSA.
UniProt ID	P18031

Handling & Storage

Handling	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Adding value to botanical resources: Metabolic network analysis along with high-resolution bioassays screening and UHPLC-qToF-high-resolution MS/MS profiling detail the pharmacological potential of underexplored Latin-American plants: C. Liang, et al.; Fitoterapia 185, 106748 (2025), Abstract
Eremane, viscidane and isozizaene diterpenoids from the leaves of Eremophila rigida and their absolute configurations: Liang, C., Ndi, C., et al.; Phytochemistry 219, 113972 (2024), Abstract
Identification of new PTP1B-inhibiting decipiene diterpenoid esters from Eremophila clarkei by high-resolution PTP1B inhibition profiling, enzyme kinetics analysis, and molecular docking: Liang, C., Zang, J., et al.; Bioorg. Chem. 139, 106744 (2023), Abstract
Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycemic drug leads: Petersen, M. J., Liang, C., et al.; Phytochemistry 196, 113072 (2022), Abstract
Effects of KY-903, a Novel Tetrazole-Based Peroxisome Proliferator-Activated Receptor γ Modulator, in Male Diabetic Mice and Female Ovariectomized Rats: Y. Ito, et al.; Biol. Pharm. Bull. 44, 659 (2021), Abstract
PTP1B inhibition studies of biological active phloroglucinols from the rhizomes of Dryopteris crassirhizoma: Kinetic properties and molecular docking simulation: N.V. Phong, et al.; Int. J. Biol. Macromol. 1889, 719 (2021), Abstract
Structure Elucidation of Prenyl- and Geranyl-Substituted Coumarins in Gerbera piloselloides by NMR Spectroscopy, Electronic Circular Dichroism Calculations, and Single Crystal X-ray Crystallography: Li, T., Ma, X., et al.; Molecules 25, (2020), Abstract
Cell penetrable, clickable and tagless activity-based probe of human cathepsin L: D. Dana, et al.; Bioorg. Chem. 85, 505 (2019), Application(s): Activity assay, Abstract
Quadruple high-resolution α-glucosidase/α-amylase/PTP1B/radical scavenging profiling combined with high-performance liquid chromatography-high-resolution mass spectrometry-solid-phase extraction-nuclear magnetic resonance spectroscopy for identification of antidiabetic constituents in crude root bark of Morus alba L: Y. Zhao, et al.; J. Chromatogr. A 1556, 55 (2018), Abstract
Absolute Structures of Wedelolide Derivatives and Structure-Activity Relationships of Protein Tyrosine Phosphatase 1B Inhibitory ent-Kaurene Diterpenes from Aerial Parts of Wedelia spp. Collected in Indonesia and Japan: D.B. Abdjul, et al.; Chem. Pharm. Bull. (Tokyo) 66, 682 (2018), Abstract — Full Text

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Last modified: May 29, 2024

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PTP1B (human), (recombinant)

BML-SE332

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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