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Pterostilbene

ALX-385-034

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CYP1A1 inhibitor

Cell permeable natural methoxylated analog of resveratrol (Prod. No. BML-FR104). Antioxidant, antiproliferative, anti-inflammatory, anti-hyperglycemic and anti-diabetic agent. Induces apoptosis. Induces Autophagy. Very potent inhibitor of cytochrome P450 1A1 (CYP1A1) with K_i=0.57µM.Inhibits activator protein 1 (AP-1) and NF-κB activation. Moderately inhibits COX-1 and COX-2 (IC₅₀=19.8µM and 83.9µM).

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Product Details

Alternative Name	trans-3,5-Dimethoxy-4’-hydroxystilbene
Appearance	Off-white to light brown powder.
CAS	537-42-8
Couple Target	COX, Jun
Couple Type	Inhibitor
Formula	C₁₆H₁₆O₃
Identity	Identity determined by MS and 1H-NMR.
MW	256.3
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (20mg/ml) or methanol; insoluble in water.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light and oxygen.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A comparison of resveratrol and other polyphenolic compounds on Notch activation and endothelial cell activity: B. LaFoya, et al.; PLoS One 14, e0210607 (2019), Abstract — Full Text
The effects of resveratrol and selected metabolites on the radiation and antioxidant response: Fabre, K. M., Saito, K., et al.; Cancer Biol. Ther. 12, 915 (2011), Abstract
Pharmacometrics of pterostilbene: preclinical pharmacokinetics and metabolism, anticancer, antiinflammatory, antioxidant and analgesic activity: C.M. Remsberg, et al.; Phytother. Res. 22, 169 (2008), Abstract
Identification of molecular pathways affected by pterostilbene, a natural dimethylether analog of resveratrol: Z. Pan, et al.; BMC Med. Genomics 1, 7 (2008), Abstract — Full Text
In vitro evaluation of the cytotoxic and anti-proliferative properties of resveratrol and several of its analogs: B. Billack, et al.; Cell. Mol. Biol. Lett. 13, 553 (2008), Abstract
Pterostilbene is equally potent as resveratrol in inhibiting 12-O-tetradecanoylphorbol-13-acetate activated NFkappaB, AP-1, COX-2, and iNOS in mouse epidermis: M. Cichocki, et al.; Mol. Nutr. Food Res. 52, S62 (2008), Abstract
Pterostilbene suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages: M.H. Pan, et al.; J. Agric. Food Chem. 56, 7502 (2008), Abstract
Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats: N. Suh, et al.; Clin. Cancer Res. 13, 350 (2007), Abstract — Full Text
Pterostilbene induces apoptosis and cell cycle arrest in human gastric carcinoma cells: M.H. Pan, et al.; J. Agric. Food Chem. 55, 7777 (2007), Abstract
Inhibition of human recombinant cytochromes P450 CYP1A1 and CYP1B1 by trans-resveratrol methyl ethers: R. Mikstacka, et al.; Mol. Nutr. Food Res. 51, 517 (2007), Abstract

Related Products

Resveratrol

BML-FR104

Antioxidant. SIRT1 activator.

38 citations

Alternative Name	trans-3,4′,5-Trihydroxystilbene
CAS	501-36-0
Couple Type	Activator, Inhibitor, Ligand
Purity	≥98% (HPLC)

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Pterostilbene

ALX-385-034

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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