PTEN (human), (recombinant) (His-tag)

PTEN (phosphatase and tensin homologue deleted on chromosome 10, MMAC) is a lipid phosphatase which can also act as a tyrosine, serine and threonine protein phosphatase. It is specific for acidic substrates such as phosphatidylinositol(3,4,5)-trisphosphate, which is its main biological substrate that mediates growth factor-induced activation of intracellular signalling through the serine-threonine kinase Akt. The tumor suppressor gene, PTEN, also known as MMAC1 or TEP1, has been isolated from a locus on chromosome 1Oq23; this protein is deleted or mutated in a large number of tumors. Germline mutations of PTEN have been identified in Cowden disease, Lhermitte-Duclos disease, and Bannayan-Zonana syndrome.