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Pseudolaric acid B

ALX-350-108

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Tubulin ligand

Activates PPARα and the phospholipase C (PLC) signalling pathway. Stimulates peroxisomal fatty acyl-CoA oxidase activity. These effects can be blocked by staurosporine (Prod. No. ALX-380-014). Exhibits significant cytotoxic activities against numerous tumor cell lines. Binds tubulin. Inhibits angiogenesis. Reduces HIF-1α protein levels. Induces apoptosis. Antifungal.

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Product Details

Alternative Name	Pseudolarix acid B, PLAB, PAB
Appearance	Off-white to light brown solid.
CAS	82508-31-4
Couple Target	Tubulin
Couple Type	Ligand
Formula	C₂₃H₂₈O₈
MW	432.5
Purity	≥95% (HPLC)
RTECS	KJ4620000
Solubility	Soluble in DMSO, 100% ethanol or chloroform.
Source	Isolated from Pseudolarix kaempferi.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from moisture.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Structural modification of an angiogenesis inhibitor discovered from traditional chinese medicine and a structure-activity relationship study: S.P. Yang, et al.; J. Med. Chem. 51, 77 (2008), Abstract
Herbal diterpenoids induce growth arrest and apoptosis in colon cancer cells with increased expression of the nonsteroidal anti-inflammatory drug-activated gene: J.K. Ko, et al.; Eur. J. Pharmacol. 559, 1 (2007), Abstract
Pseudolarix acid B, a new tubulin-binding agent, inhibits angiogenesis by interacting with a novel binding site on tubulin: Y.G. Tong, et al.; Mol. Pharmacol. 69, 1226 (2006), Abstract
Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death: X. Gong, et al.; Exp. Mol. Med. 38, 428 (2006), Abstract — Full Text
Studies on anti-tumour activities of pseudolaric acid-B (PLAB) and its mechanism of action: B. Liu, et al.; J. Asian Nat. Prod. Res. 8, 241 (2006), Abstract
Pseudolaric acid B induces apoptosis through p53 and Bax/Bcl-2 pathways in human melanoma A375-S2 cells: X.F. Gong, et al.; Arch. Pharm. Res. 28, 68 (2005), Abstract
Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo: V.K. Wong, et al.; Clin. Cancer Res. 11, 6002 (2005), Abstract
Effect of pseudolaric acid B on gastric cancer cells: inhibition of proliferation and induction of apoptosis: K.S. Li, et al.; World J. Gastroenterol. 11, 7555 (2005), Abstract — Full Text
Pseudolarix acid B inhibits angiogenesis by antagonizing the vascular endothelial growth factor-mediated anti-apoptotic effect: W.F. Tan, et al.; Eur. J. Pharmacol. 499, 219 (2004), Abstract
Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1alpha by promoting proteasome-mediated degradation: M.H. Li, et al.; Clin. Cancer Res. 10, 8266 (2004), Abstract

Related Products

Staurosporine

ALX-380-014

Apoptosis inducer. Protein kinase inhibitor.

112 citations

Alternative Name	Antibiotic AM-2282
CAS	62996-74-1
Couple Type	Inhibitor
Purity	≥99% (HPLC)

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Pseudolaric acid B

ALX-350-108

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