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Pseudohypericin

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Inhibitor of PKC and dopamine β-hydroxylase

Inhibitor of protein kinase C (PKC) (IC₅₀=15µg/ml). Antiviral and antiretroviral activity. Potent inhibitor of dopamine-β-hydroxylase (IC₅₀=3µg/ml).

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Appearance	Black to black-red powder.
CAS	55954-61-5
Couple Target	Dopamine beta-hydroxylase, PKC
Couple Type	Inhibitor
Formula	C₃₀H₁₆O₉
MW	520.5
Purity	≥98% (HPLC, TLC)
Solubility	Soluble in methanol, 100% ethanol, DMSO, acetone and other organic solvents.
Source	Isolated from Hypericum perforatum.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Antagonist effect of pseudohypericin at CRF1 receptors: U. Simmen, et al.; Eur. J. Pharmacol. 458, 251 (2003), Abstract
Phototoxic and apoptosis-inducing capacity of pseudohypericin: C.M. Schempp, et al.; Planta Med. 68, 171 (2002), Abstract
Biochemical activities of extracts from Hypericum perforatum L. 5th communication: dopamine-beta-hydroxylase-product quantification by HPLC and inhibition by hypericins and flavonoids: A. Denke, et al.; Arzneimittelforschung 50, 415 (2000), Abstract
Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin: G. Lavie, et al.; PNAS 86, 5963 (1989), Abstract
Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity: I. Takahashi, et al.; BBRC 165, 1207 (1989), Abstract
Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin: D. Meruelo, et al.; PNAS 85, 5230 (1988), Abstract
Zur Isolierung und Konstitution des Pseudohypericins: H. Brockmann, et al.; Tetrahedron Lett. 15, 1991 (1974)
Zur Isolierung und Konstitution des Pseudohypericins: H. Brockmann, et al.; Tetrahedron Lett. 15, 1991 (1974)

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