Home Shop [pSer239]VASP monoclonal antibody (16C2)

[pSer239]VASP monoclonal antibody (16C2)

ALX-804-240

12 citations

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This antibody is covered by our Worry-Free Guarantee.

which are cleaved into the intermediate forms p43 and p41 and finally processed to the active p18 subunit (filled arrowheads)." — which are cleaved into the intermediate forms p43 and p41 and finally processed to the active p18 subunit (filled arrowheads).”

Product Details

Alternative Name	Vasodilator stimulated phosphoprotein
Application	ELISA, Flow Cytometry, ICC, IP, WB
Clone	16C2
Crossreactivity	Does not cross-react with the non-phosphorylated form of VASP.
Formulation	Lyophilized from 1ml of 2x PBS containing 0.09% sodium azide, PEG, and sucrose.
Host	Mouse
Immunogen	Synthetic peptide corresponding to a portion of VASP (vasodilator stimulated phosphoprotein) phosphorylated at Ser239 (RKVpSKQE) conjugated to KLH.
Isotype	IgG1
Purity Detail	Thiophilic adsorption and size exclusion chromatography purified.
Recommendation Dilutions/Conditions	ELISA (use at 0.05µg/ml)Immunocytochemistry (use at 1-10µg/ml; may tolerate 0.5% formaldehyde fixation) , Immunoprecipitation (use 1-10 µg per 106 pervanadate-treated A431 cells)Western Blot (1µg/ml for AP/BCIP/NBT (MTT) detection; 0.5µg/ml for HRPO/ECL detection; recommended blocking buffer BPPT: 2x PBS 3% (w/v) BSA, 1% (w/v) PEG 4,000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Reconstitution	Reconstitute with 1ml water (15 minutes at room temperature).
Species Reactivity	Human, Mouse, Rabbit, Rat
Specificity	Recognizes Ser²³⁹-phosphorylated VASP.
Technical Info / Product Notes	Important! The use of MAb to VASP (activated) (Ser²³⁹) (16C2) for diagnostic or therapeutic purposes is patented! The antibody is supplied for research use only!
UniProt ID	P50552
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Use/Stability	Stable at -80°C up to 1 year, at 4°C up to 3 months.
Handling	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and freeze in liquid nitrogen.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

A conjugate of decyltriphenylphosphonium with plastoquinone can carry cyclic adenosine monophosphate, but not cyclic guanosine monophosphate, across artificial and natural membranes: A.M. Firsov, et al.; Biochim. Biophys. Acta 1860, 329 (2018), Abstract
Dual roles of quercetin in platelets: phosphoinositide-3-kinase and MAP kinases inhibition, and cAMP-dependent vasodilator-stimulated phosphoprotein stimulation: W.J. Oh, et al.; Evid. Based Complement Alternat. Med. 2012, 485262 (2012), Application(s): Western blot, Abstract — Full Text
Acyl derivatives of coenzyme A inhibit platelet function via antagonism at P2Y1 and P2Y12 receptors: a new finding that may influence the design of anti-thrombotic agents: P. Manolopoulos, et al.; Platelets 19, 134 (2008), Abstract — Full Text
The active metabolite of prasugrel effectively blocks the platelet P2Y12 receptor and inhibits procoagulant and pro-inflammatory platelet responses: H.M. Judge, et al.; Platelets 19, 125 (2008), Abstract
Dual actions of dephostatin on the nitric oxide/cGMP-signalling pathway in porcine iliac arteries: A.A. Persson, et al.; Eur. J. Pharmacol. 521, 124 (2005), Application(s): Western blot, Abstract
The activity of constitutive nitric oxide synthase is increased by the pathway cAMP/cAMP-activated protein kinase in human platelets. New insights into the antiaggregating effects of cAMP-elevating agents.: I. Russo, et al.; Thromb. Res. 114, 265 (2004), Application(s): Western blot, Abstract
Characterisation of GEA 3175 on human platelets;: comparison with S-nitroso-N-acetyl-D, L-penicillamine: A.K. Asplund Persson, et al.; Eur. J. Pharmacol. 496, 1 (2004), Application(s): Western blot, Abstract
Cyclic nucleotides modulate store-mediated calcium entry through the activation of protein-tyrosine phosphatases and altered actin polymerization in human platelets: J.A. Rosado, et al.; J. Biol. Chem. 276, 15666 (2001), Abstract — Full Text
Effects of In Vivo Nitroglycerin Treatment on Activity and Expression of the Guanylyl Cyclase and cGMP-Dependent Protein Kinase and Their Downstream Target Vasodilator-Simulated Phosphoprotein in Aorta: A. Mülsch, et al.; Circulation 103, 2188 (2001), Abstract — Full Text
KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells: M. Burkhardt, et al.; J. Biol. Chem. 275, 33536 (2000), Abstract — Full Text

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[pSer239]VASP monoclonal antibody (16C2)

ALX-804-240

Product Details

Handling & Storage

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