Home Shop [pSer19]αB-Crystallin polyclonal antibody

[pSer¹⁹]αB-Crystallin polyclonal antibody

ADI-SPA-225

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Alpha-crystallins, which are part of the small Heat shock family members, are major water-soluble proteins present in the lens of the mammalian eye. Phosphorylation of serine residues which occurs during development and in response to stress, is intimately linked with its function. Chaperone activity requires, and is modulated by, oligomerization and is limited to binding unfolded intermediates to prevent irreversible aggregation.

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[pSer19]αB-Crystallin polyclonal antibody Western blot

Product Details

Alternative Name	CRYAB, HSPB5
Application	IP, WB
Formulation	Liquid. In sodium phosphate buffer, pH 7.0, containing 3% BSA.
Host	Rabbit
Immunogen	Synthetic peptide corresponding to a portion of human αB-crystallin. The sequence is completely conserved in mouse, rat and bovine phosphorylated at Ser19.
Recommendation Dilutions/Conditions	Immunoprecipitation (12.5µg/ml)Western Blot (1µg/ml, colorimetric)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Source	Purified from rabbit serum.
Species Reactivity	Bovine, Human, Mouse
UniProt ID	P02511
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Phosphorylation of the chaperone-like HspB5 rescues trafficking and function of F508del-CFTR: F. Degrugillier, et al.; Int. J. Mol. Sci. 21, E4844 (2020), Application(s): Western-blot using CFBE cells, Abstract
Biomarker-based assessment of the muscle maintenance and energy status of anurans from an extremely seasonal semi-arid environment, the Brazilian Caatinga: Madelaire, C. B., Gomes, F. R., et al.; Comp. Biochem. Physiol. A Mol. Integr. Physiol. 240, 110590 (2020), Abstract
Upregulation and phosphorylation of HspB1/Hsp25 and HspB5/αB-crystallin after transient middle cerebral artery occlusion in rats: B. Bartelt-Kirbach, et al.; Cell Stress Chaperones 22, 653 (2017), Application(s): IHC / Reactant(s) Rat, Abstract — Full Text
AlphaB-crystallin expression correlates with aging deficits in the peripheral nervous system: E.M.F. Lim, et al.; Neurobiol. Aging 53, 318 (2017), Application(s): Western-blot using mouse sciatic nerve lysates, Abstract
Phosphorylation and degradation of αB-crystallin during enterovirus infection facilitates viral replication and induces viral pathogenesis: G. Fung, et al.; Oncotarget 8, 74767 (2017), Application(s): Western-blot using HL-1 cells and mouse cardiac tissue, Abstract — Full Text
Alpha B-Crystallin Protects Rat Articular Chondrocytes against Casein Kinase II Inhibition-Induced Apoptosis: S.W. Lee, et al.; PLoS One 11, e0166450 (2016), Abstract — Full Text
HSP90 inhibitors in the context of heat shock and the unfolded protein response: effects on a primary canine pulmonary adenocarcinoma cell line: A.N. Graner, et al.; Int. J. Hyperthermia 20, 1 (2016), Application(s): WB / Reactant(s) Dog, Abstract — Full Text