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Protoporphyrin IX (free acid)

ALX-430-041

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Guanylyl cyclase activator

Protoporphyrin IX free acid, as distinct from its zinc salt (which inhibits heme oxygenase), activates soluble guanylyl cyclase (sGC) by binding directly to the enzyme. A useful reagent in cases where the use of nitric oxide (NO) or nitric oxide donors is undesirable.

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Product Details

Alternative Name	8,13-Divinyl-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid
Appearance	Purple to dark brown solid.
CAS	553-12-8
Couple Target	Guanylyl cyclase
Couple Type	Activator
Formula	C₃₄H₃₄N₄O₄
Identity	Determined by NMR and UV/VIS.
MI	14: 7897
MW	562.7
Purity	≥95% (HPLC)
Solubility	Dissolve initially in 0.1M base (Tris base or NaOH), then add water miscible organic solvent (EtOH (10mg/ml), MeOH, DMSO (10mg/ml), DMF) until solution is 50/50 base/solvent. When a clear solution is obtained, it can be diluted into an aqueous medium and titrated or buffered to any pH>7. Use immediately.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Make solutions fresh daily.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The Histamine Pathway is a Target to Treat Hepatic Experimental Erythropoietic Protoporphyria: Kuo, N., Li, P., et al.; Cell. Mol. Gastroenterol. Hepatol. 19, 101463 (2025), Abstract
Challenges in, and recommendations for, hyperspectral imaging in ex vivo malignant glioma biopsy measurements: A. Walke, et al.; Sci. Rep. 13, 3829 (2023), Abstract
Immune responses in beta-thalassaemia: heme oxygenase 1 reduces cytokine production and bactericidal activity of human leucocytes: A. Nithichanon, et al.; Sci. Rep. 10, 10297 (2020), Abstract — Full Text
Xenosiderophore Utilization Promotes Bacteroides thetaiotaomicron Resilience during Colitis: Zhu, W., Winter, M. G., et al.; Cell Host Microbe 27, 376 (2020), Abstract
Photodynamic intramolecular crosslinking of myoglobin: J. van Steveninck & T.M.A.R. Dubbelman; Biochim. Biophys. Acta 791, 98 (1984)
Porphyrins and chlorophylls as probes for fluoroimmunoassays [letter]: J.L. Hendrix; Clin. Chem. 29, 1003 (1983), Abstract
Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme: M.S. Wolin, et al.; J. Biol. Chem. 257, 13312 (1982), Abstract — Full Text
Model studies on photodynamic cross-linking: H. Verweij & J. Van Steveninck; Photochem. Photobiol. 35, 265 (1982), Abstract

Last modified: May 29, 2024

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Protoporphyrin IX (free acid)

ALX-430-041

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Handling & Storage

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