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The human intracellular serpin proteinase inhibitor 9 (PI9) is the only human protein able to inhibit the activity of the serine protease granzyme B. Granzyme B is expressed by cytotoxic lymphocytes and induces rapid target cell apoptosis.
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Figure 2: The following tumors were stained for PI9: a) B-CLL and b) classical Hodgkin disease, nodular sclerosing subtype.
Figure 1: Tissue sections of T-ALCL a) stained with MAb to PI9 (Prod. No. ALX-804-457) and b) double-stained with MAb to PI9 (red) (Prod. No. ALX-804-457) and granzyme B (brown). In panel b the arrows point to tumor-infiltrating CTLs positive for granzyme B and the arrowhead denotes an example of a PI9+ neoplastic cell.”””””
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