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Pseudosubstrate sequence from PKCα and ß. Highly specific inhibitor, which is N-terminal myristoylated to allow membrane permeability. IC50=8 µM for TPA activation of MARCKS phosphorylation in fibroblast primary cultures, and 98% inhibition at 100 µM. Partially reverses multidrug resistance in human breast cancer cells.
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Last modified: May 29, 2024