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Proteasome substrate IV (fluorogenic)

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Fluorogenic substrate for Alzheimer’s Disease amyloid A4-generating enzymes and for the proteasome.

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Alternative Name	Z-VKM-AMC, Z-Val-Lys-Met-AMC
Appearance	White powder.
Formula	C₃₄H₄₅N₅O₇S
MW	667.8
Purity	≥98%
Sequence	Z-Val-Lys-Met-AMC (AMC=7-Amino-4-methylcoumarin)
Solubility	Soluble in DMSO.
Technical Info / Product Notes	AMC has an excitation maximum of 340-360nm and an emission maximum of 440-460nm.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells: R.C. Gardner, et al.; Biochem. J. 346, 447 (2000), Abstract — Full Text
Distribution of Alzheimer’s disease amyloid A4-generating enzymes in rat brain tissue: S. Ishiura, et al.; Neurosci. Lett. 115, 329 (1990), Abstract

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