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Proteasome inhibitor II (aldehyde)

ALX-260-090

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Potent and cell permeable proteasome inhibitor. Inhibits the chymotrypsin-like activity of the 26S proteasome (MCP; multicatalytic proteinase complex). Does not inhibit the peptidylglutamyl-peptide hydrolyzing activity of the MPC.

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Product Details

Alternative Name	Z-LLF-CHO, Z-Leu-Leu-Phe-CHO
Appearance	White to off-white powder.
Formula	C₂₉H₃₉N₃O₅
MW	509.7
Purity	≥95% (HPLC)
Sequence	Z-Leu-Leu-Phe-CHO
Solubility	Soluble in DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Dominant signals leading to inhibitor kappaB protein degradation mediate CD40 ligand rescue of WEHI 231 immature B cells from receptor-mediated apoptosis: S.L. Schauer, et al.; J. Immunol. 160, 4398 (1998), Abstract — Full Text
Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes): M. Orlowski, et al.; Biochemistry 36, 13946 (1997), Abstract — Full Text
Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids: M. Orlowski, et al.; Biochemistry 32, 1563 (1993), Abstract

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Proteasome inhibitor II (aldehyde)

ALX-260-090

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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