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Proteasome inhibitor I (aldehyde)

ALX-260-089

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Cell permeable inhibitor of the 26S proteasome (MCP; multicatalytic proteinase complex) in HT4 cells. Causes accumulation of ubiquitinylated proteins in neuronal cells. Prevents the activation of NF-κB in response to TNF-α or okadaic acid (Prod. No. ALX-350-003) through inhibition of IκBα degradation.

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Product Details

Alternative Name	Z-IE(OtBu)AL-CHO, Z-Ile-Glu(OtBu)-Ala-Leu-CHO, PSI
Appearance	White powder.
Formula	C₃₂H₅₀N₄O₈
MW	618.8
Purity	≥95% (TLC)
Sequence	Z-Ile-Glu(OtBu)-Ala-Leu-CHO
Solubility	Soluble in 100% ethanol (30mg/ml), DMSO (30mg/ml) or methanol (50mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B: J.M. Griscavage, et al.; PNAS 93, 3308 (1996), Abstract — Full Text
Degradation process of ligand-stimulated platelet-derived growth factor beta-receptor involves ubiquitin-proteasome proteolytic pathway: S. Mori, et al.; J. Biol. Chem. 270, 29447 (1995), Abstract — Full Text
A new inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20S proteasome) induces accumulation of ubiquitin- protein conjugates in a neuronal cell: M.E. Figueiredo-Pereira, et al.; J. Neurochem. 63, 1578 (1994), Abstract
A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B: E.B. Traenckner, et al.; EMBO J. 13, 5433 (1994), Abstract

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Inhibitor of PP1 and PP2A

64 citations

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CAS	78111-17-8
Couple Type	Inhibitor
Purity	≥98% (HPLC, TLC)

ALX-350-003-M001 — 1 mg

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Okadaic acid (high purity) quantity

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Proteasome inhibitor I (aldehyde)

ALX-260-089

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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