Home Shop Proteasome 20S (human), (purified)

Proteasome 20S (human), (purified)

BML-PW8720

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High integrity preparation for use in proteasome research.

The 20S proteasome is the catalytic core of the 26S proteasome, the central protease of the ubiquitin pathway of protein degradation. Unlike the 26S proteasome, which degrades proteins in an ATP-dependent manner, the 20S proteasome is ATP-independent and only degrades entirely unfolded polypeptides.

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Product Details

Concentration	1.0mg/ml
Formulation	Liquid. In 20mM TRIS-HCl, pH 7.2, containing 1mM EDTA, 1mM DTT, 1mM sodium azide and 50% glycerol.
Source	Isolated and purified from human erythrocytes.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. 20S Proteasome remains relatively stable and active so long as repetitive freeze-thaw cycles are avoided. It has been demonstrated that 20S proteasome undergoes only slow loss of activity when stored at 4°C for up to six months. If it is to be used on a regular basis, it is recommended that the material should be stored between 0°C-4°C during the duration of use. For longer term storage the material may be dispensed as single use aliquots and stored at -80°C.
Handling	Avoid freeze/thaw cycles.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Nuclear p62/SQSTM1 facilitates ubiquitin-independent proteasomal degradation of BMAL1: Zhang, C., Wu, Q., et al.; PLoS Genet. 21, e1011794 (2025), Abstract
Characterization of the cystargolide biosynthetic gene cluster and functional analysis of the methyltransferase CysG: P. Beller, et al.; J. Biol. Chem. 300, 105507 (2024), Abstract
Integrated transcriptomics- and structure-based drug repositioning identifies drugs with proteasome inhibitor properties: Larsson, P., De Rosa, M. C., et al.; Sci. Rep. 14, 18772 (2024), Abstract
Protein degradation by human 20S proteasomes elucidates the interplay between peptide hydrolysis and splicing: Soh, W. T., Roetschke, H. P., et al.; Nat. Commun. 15, 1147 (2024), Abstract
Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models: E.S. Chocron, et al.; Sci. Adv. 8, abk2252 (2022), Abstract
Extracellular 20S proteasome secreted via microvesicles can degrade poorly folded proteins and inhibit Galectin-3 agglutination activity: A. Bonhoure, et al.; Traffic 23, 287 (2022), Abstract
A ubiquitin-independent proteasome pathway controls the CARD8 inflammasome: Hsiao, J. C., Neugroschl, A. R., et al.; bioRxiv , (2022)
A ubiquitin-independent proteasome pathway controls activation of the CARD8 inflammasome: Hsiao, J. C., Neugroschl, A. R., et al.; J. Biol. Chem. 298, 102032 (2022), Abstract
Chemical Elicitors Induce Rare Bioactive Secondary Metabolites in Deep-Sea Bacteria under Laboratory Conditions: R. de Felício, et al.; Metabolites 11, 107 (2021), Abstract — Full Text
A putative amphipathic alpha helix in hepatitis B virus small envelope protein plays a critical role in the morphogenesis of subviral particles: Yang, S., Shen, Z., et al.; J. Virol. 95, (2021), Abstract

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Proteasome 20S (human), (purified)

BML-PW8720

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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