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Western blot analysis of Proteasome 20S β1 subunit, mAb (MCP421) (Prod. No. BML-PW8140): Lane 1: MW marker, Lane 2: HeLa (Prod. No. ADI-LYC-HL100), Lane 3: HeLa S100 fraction (Prod. No. BML-SW8750), Lane 4: 3T3 (Prod. No. ADI-LYC-3T100).
Product Details
| Alternative Name |
Proteasome subunit β type-6, Macropain δ chain, Proteasome subunit Y |
|---|---|
| Application |
IHC, WB |
| Clone |
MCP421 |
| Formulation |
Liquid. In PBS containing 10mM sodium azide. |
| Gene/Protein Identifier |
PSMB6 (gene name) |
| Host |
Mouse |
| Immunogen |
Dinitrophenylated proteasomes. |
| Isotype |
IgG1 |
| Purity Detail |
Protein G-affinity purified ascites. |
| Source |
Purified from mouse ascites. |
| Species Reactivity |
Human, Rabbit, Yeast |
| Specificity |
Recognizes the β1 subunit of the 20S proteasome. |
| Technical Info / Product Notes |
Various systems for the nomenclature of the proteasome subunits have been established. This may be a source of confusion as the system on UniProt differs from “standard” nomenclature as described in the literature. The UniProt ID and Gene Name will help to clearly identify the proteins. |
| UniProt ID |
P28072 |
| Worry-free Guarantee |
This antibody is covered by our Worry-Free Guarantee. |
Handling & Storage
| Handling |
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
|---|---|
| Long Term Storage |
-20°C |
| Shipping |
Blue Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Role of TRIM24 in the regulation of proteasome-autophagy crosstalk in bortezomib-resistant mantle cell lymphoma: Bouvier, C., Gonzalez-Santamarta, M., et al.; Cell Death Discov. 11, 108 (2025), Abstract
- Loss-of-function mutations in the dystonia gene THAP1 impair proteasome function by inhibiting PSMB5 expression.: Ramage, D. E., Grant, D. W., et al.; Nat. Commun. 16, 1511 (2025), Reactant(s): Human, Abstract
- Comparative Study of Cutaneous Squamous Cell Carcinogenesis in Different Hairless Murine Models: Gkikas, G., Katsiris, D., et al.; Cancers (Basel) 16, 3546 (2024), Abstract
- Oleuropein enhances proteasomal activity and reduces mutant huntingtin-induced cytotoxicity.: Huang, Z. N., Lee, S. Y., et al.; Front. Pharmacol. 15, 1459909 (2024), Application(s): WB / Reactant(s): Mouse, Abstract
- Healthspan improvement and anti-aggregation effects induced by a marine-derived structural proteasome activator: M.A. Vasilopoulou, et al.; Redox Biol. 56, 10262 (2022), Abstract
- The role of Cycloastragenol at the intersection of Nrf-2/ARE, telomerase, and proteasome activity: Kırmızıbayrak, P. B., Yılmaz, S., et al.; bioRxiv , (2022), Reactant(s): Human
- The role of cycloastragenol at the intersection of NRF2/ARE, telomerase, and proteasome activity.: Yılmaz, S., Bedir, E., et al.; Free Radic. Biol. Med. 188, 105 (2022), Application(s): ChIP / Reactant(s): Human, Abstract
- Red Blood Cell Proteasome in Beta-Thalassemia Trait: Topology of Activity and Networking in Blood Bank Conditions: A.T. Anastasiadi, et al.; Membranes 11, 716 (2021), Abstract
- Resveratrol confers neuroprotection against high-fat diet in a mouse model of Alzheimer’s disease via modulation of proteolytic mechanisms: Sarroca, S., Gatius, A., et al.; J. Nutr. Biochem. 89, 108569 (2021), Abstract
- The Proteasome Activators Blm10/PA200 Enhance the Proteasomal Degradation of N-Terminal Huntingtin: Aladdin, A., Yao, Y., et al.; Biomolecules 10, (2020), Abstract
- Proteasome Subunits Differentially Control Myeloma Cell Viability and Proteasome Inhibitor Sensitivity.: Stewart, W., Shi, C. X., et al.; Mol. Cancer Res. 18, 1453 (2020), Application(s): WB / Reactant(s): Human, Abstract
- An SOD1 deficiency aggravates proteasome inhibitor bortezomib-induced testicular damage in mice: T. Homma & J. Fujii; Biochim. Biophys. Acta Gen. Subj. 1863, 1108 (2019), Application(s): Mouse cryosectioned tissue, Abstract
- Novel cell line models to study mechanisms and overcoming strategies of proteasome inhibitor resistance in multiple myeloma: D. Brunnert, et al.; Biochim. Biophys. Acta Mol. Basis Dis. 1865, 1666 (2019), Abstract
- Potential involvement of ubiquitin-proteasome system dysfunction associated with oxidative stress in the pathogenesis of sickle cell disease: Warang, P., Homma, T., et al.; Br. J. Haematol. 182, 559 (2018), Abstract
- Heterozygous Truncating Variants in POMP Escape Nonsense-Mediated Decay and Cause a Unique Immune Dysregulatory Syndrome.: Lupski, J. R., Gibbs, R. A., et al.; Am. J. Hum. Genet. 102, 1126 (2018), Application(s): WB / Reactant(s): Human, Abstract
- Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival: S. Benvegnu, et al.; Mol. Cell 66, 358 (2017), Abstract
- Detection of active proteasome structures in brain extracts: proteasome features of August rat brain with violations in monoamine metabolism: P.A. Erokhov, et al.; Oncotarget 8, 70695 (2017), Application(s): WB / Reactant(s) Rat, Abstract — Full Text
- Circadian modulation of proteasome activity and accumulation of oxidized protein in human embryonic kidney HEK 293 cells and primary dermal fibroblasts: A. Desvergne, et al.; Free Radic. Biol. Med. 94, 195 (2016), Application(s): Western blot, Abstract
- Major Histocompatibility Complex (MHC) Class I Processing of the NY-ESO-1 Antigen Is Regulated by Rpn10 and Rpn13 Proteins and Immunoproteasomes following Non-lysine Ubiquitination: Golnik, R., Lehmann, A., et al.; J. Biol. Chem. 291, 8805 (2016), Abstract
- Protein Expression of Proteasome Subunits in Elderly Patients with Schizophrenia: Scott, M. R., Rubio, M. D., et al.; Neuropsychopharmacology 41, 896 (2016), Abstract
- Ubiquitin-independent proteosomal degradation of myelin basic protein contributes to development of neurodegenerative autoimmunity: A. Belogurov Jr, et al.; FASEB J. 29, 1901 (2015), Application(s): WB / Reactant(s) Mouse, Abstract — Full Text
- SOD1 deficiency decreases proteasomal function, leading to the accumulation of ubiquitinated proteins in erythrocytes: T. Homma, et al.; Arch. Biochem. Biophys. 583, 65 (2015), Application(s): Immunoblotting, Abstract
- The GST-BHMT assay reveals a distinct mechanism underlying proteasome inhibition-induced macroautophagy in mammalian cells: Y.N. Rui, et al.; Autophagy 11, 812 (2015), Abstract — Full Text
- Skeletal muscle myotubes in severe obesity exhibit altered ubiquitin-proteasome and autophagic/lysosomal proteolytic flux: L.M. Bollinger, et al.; Obesity (Silver Spring) 23, 1185 (2015), Application(s): Western Blot, Abstract — Full Text
- The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells: M. Hamouda, et al.; Oncotarget 5, 6252 (2014), Application(s): Analysis of velcade resistant multiple myeloma human cells by WB, Assay, Abstract — Full Text
- Purification and separation of the 20S immunoproteasome from the constitutive proteasome and identification of the subunits by LC-MS: V. Dechavanne, et al.; Protein Exp. Purif. 87, 100 (2013), Application(s): Western blot, Abstract
- Bortezomib resistance in a myeloma cell line is associated to PSMβ5 overexpression and polyploidy: P. Balsas, et al.; Leuk. Res. 36, 212 (2012), Application(s): Western blot, Abstract
- TRIM5α associates with proteasomal subunits in cells while in complex with HIV-1 virions: Z. Lukic, et al.; Retrovirology 8, 93 (2011), Abstract — Full Text
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