Home Shop Proteasome 20S α3 subunit monoclonal antibody (MCP257)

Proteasome 20S α3 subunit monoclonal antibody (MCP257)

BML-PW8115

9 citations

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Product Details

Alternative Name	Proteasome subunit α type-4, Macropain subunit C9, Proteasome subunit L
Application	IHC, WB
Clone	MCP257
Formulation	Liquid. In PBS containing 10mM sodium azide.
Gene/Protein Identifier	PSMA4 (gene name)
Host	Mouse
Immunogen	Human placenta derived proteasomes.
Isotype	IgG2b
Purity Detail	Partially purified ascites.
Source	Purified from hybridoma tissue culture supernatant.
Species Reactivity	Human, Mouse, Rabbit, Rat
Specificity	Recognizes the α3 subunit of the 20S proteasome.
Technical Info / Product Notes	Various systems for the nomenclature of the proteasome subunits have been established. This may be a source of confusion as the system on UniProt differs from “standard” nomenclature as described in the literature. The UniProt ID and Gene Name will help to clearly identify the proteins.
UniProt ID	P25789
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Handling & Storage

Handling	Avoid freeze/thaw cycles.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Purification and characterization of different proteasome species from mammalian cells: I. Byuin, et al.; STAR Protoc. 4, 102748 (2023), Abstract
Identification of candidate mitochondrial inheritance determinants using the mammalian cell-free system: Zuidema, D., Jones, A., et al.; Elife 12, (2023), Abstract
The Antipsychotic Drug Clozapine Suppresses the RGS4 Polyubiquitylation and Proteasomal Degradation Mediated by the Arg/N-Degron Pathway: Jeon, J. H., Oh, T. R., et al.; Neurotherapeutics 18, 1768 (2021), Abstract
Proteasome stress sensitizes malignant pleural mesothelioma cells to bortezomib-induced apoptosis: F. Cerruti, et al.; Sci. Rep. 7, 17626 (2017), Abstract — Full Text
Docosahexaenoic acid-mediated protein aggregates may reduce proteasome activity and delay myotube degradation during muscle atrophy in vitro: S.K. Shin, et al.; Exp. Mol. Med. 49, e287 (2017), Application(s): WB / Reactant(s) Human, Abstract — Full Text
Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia: Alghamdi, A., Vallortigara, J., et al.; J. Alzheimers Dis. 57, 373 (2017), Abstract
Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation: W.H. Choi, et al.; Nat. Commun. 7, 10963 (2016), Application(s): Western blot, Abstract
Caveolin-1 is an aggresome-inducing protein: Tiwari, A., Copeland, C. A., et al.; Sci. Rep. 6, 38681 (2016), Abstract
Direct cellular delivery of human proteasomes to delay tau aggregation: Han, D. H., Na, H. K., et al.; Nat. Commun. 5, 5633 (2014), Abstract

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Proteasome 20S α3 subunit monoclonal antibody (MCP257)

BML-PW8115

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Proteasome 20S α3 subunit monoclonal antibody (MCP257)

BML-PW8115

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