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Prostaglandin E₂

BML-PG007

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Prostanoid receptor ligand

Biosynthesis in numerous cell types. Potent vasodilator. Exerts both anti- and proinflammatory activities by inhibition of mediator release and enhancement of mediator action. Stimulates bone resorption. Synergizes with LTB4. Facilitates replication of AIDS virus. Regulates sleep/wake cycle. Thermoregulatory action in the CNS. Induces LHRH release from rat median eminence. Regulates renal hemodynamics and sodium excretion. One of the primary cyclooxygenase (COX) products of arachidonic acid and one of the most widely investigated prostaglandins.

Its activity influences inflammation, fertility and parturition, gastric mucosal integrity and immune modulation. The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4. Affinity constants (Kd) of PGE2 for these receptors range from 1-10nM depending on the receptor subtype and tissue. Regulates vertebrate hematopoietic stem cell homeostasis.

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Product Details

Alternative Name	PGE2
Appearance	White to off-white crystalline powder.
CAS	363-24-6
Couple Target	Prostanoid receptor
Couple Type	Ligand
Formula	C₂₀H₃₂O₅
MI	14: 7877
MW	352.5
Purity	≥97% (HPLC)
Solubility	Soluble in 100% ethanol, DMSO or dimethylformamide (100mg/ml); soluble in acetone. Sparingly soluble in PBS, pH 7.2 (5mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 2 years after receipt when stored at -20°C. Avoid basic solutions (pH > 7.4), since Prostaglandin E2 will degrade to PGA and PGB. We do not recommend storing aqueous solutions for more than one day.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Selective PRMT5 Inhibitors Suppress Human CD8+ T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA: Strobl, C. D., Schaffer, S., et al.; Mol. Cancer Ther. 19, 409 (2020), Abstract
Notochordal cells and tissue explants for intervetebral disc regeneration: I. Arkesteijn; , (2016), (PhD thesis), Application(s): ELISA, cytokine concentrations in tissue and medium, Full Text
Prostaglandin D2 modulates calcium signals induced by prostaglandin E2 in neurons of rat dorsal root ganglia: D. Ott, et al.; Neurosci. Lett. 597, 159 (2015), Application(s): Cell Culture, Abstract
Role of cAMP in the promotion of colorectal cancer cell growth by prostaglandin E2: Löffler, I., Grün, M., et al.; BMC Cancer 8, 380 (2008), Abstract
Paradoxical regulation by PGE-2 on release of neutrophil chemoattractants by rat bone marrow macrophages: J.W. Christman, et al.; Prostaglandins 41, 251 (1991), Abstract
Sleep-wake regulation by prostaglandins D2 and E2: O. Hayaishi; J. Biol. Chem. 263, 14593 (1988), Abstract
Enhancement of acute allergic inflammation by indomethacin is reversed by prostaglandin E2: apparent correlation with in vivo modulation of mediator release: J. Raud, et al.; PNAS 85, 2315 (1988), Abstract
Basal level of prostaglandin D2 in rat brain by a solid-phase enzyme immunoassay: O. Hiroshima, et al.; Prostaglandins 32, 63 (1986), Abstract