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Prostaglandin A2

BML-PG002

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CDK inhibitor

Blocks cell cycle at the G1 and G2/M phase [1] by inhibiting G1 phase cyclin dependent kinases [2] downregulating cyclin D1 [3]. Modulates all three aspects of the glutathione-mediated biotransformation system, i.e. GSH levels, glutathione S-transferase activity and transport of GSH conjugates [4]. Antitumor activity. Induces γ-glutamylcysteine synthetase and apoptosis in L-1210 cells.

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Product Details

Alternative Name	Medullin, Prosta-5,10,13-trien-1-oic acid, 15-hydroxy-9-oxo-, (5Z,13E,15S)-, PGA2
Appearance	Neat oil.
CAS	13345-50-1
Couple Target	CDK
Couple Type	Inhibitor
Formula	C₂₀H₃₀O₄
MW	334.5
Purity	≥98% (TLC)
Solubility	Soluble in 100% ethanol, acetone or ethyl acetate.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C.
Handling	Store at -20°C or colder. For experiments with cells or tissues, dissolve in ethanol and add aliquots directly to aqueous media. For HPLC, aliquots in acetone solution should be evaporated to dryness under a stream of nitrogen and HPLC mobile phase added to the desired concentration. Avoid basic conditions.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Down-regulation of cyclin D1 expression by prostaglandin A(2) is mediated by enhanced cyclin D1 mRNA turnover: S. Lin, et al.; Mol. Cell. Biol. 20, 7903 (2000), Abstract — Full Text
Interactions of prostaglandin A2 with the glutathione-mediated biotransformation system: M.L. van Iersel, et al.; Biochem. Pharmacol. 57, 1383 (1999), Abstract
p21Waf1 inhibits the activity of cyclin dependent kinase 2 by preventing its activating phosphorylation: M. Hitomi, et al.; Oncogene 17, 959 (1998), Abstract
Prostaglandin A2 blocks the activation of G1 phase cyclin-dependent kinase without altering mitogen-activated protein kinase stimulation: M. Hitomi, et al.; J. Biol. Chem. 271, 9376 (1996), Abstract — Full Text
Prostaglandin A2 and delta 12-prostaglandin J2 induce apoptosis in L1210 cells: I.K. Kim, et al.; FEBS Lett. 321, 209 (1993), Abstract
Growth inhibition of Friend erythroleukaemia cell tumours in vivo by a synthetic analogue of prostaglandin A: an action independent of natural killer-activity: S. Marini, et al.; Br. J. Cancer 61, 394 (1990), Abstract
Prostaglandin J2–anti-tumour and anti-viral activities and the mechanisms involved: M. Fukushima; Eicosanoids 3, 189 (1990), Abstract
Induction of gamma-glutamylcysteine synthetase by prostaglandin A2 in L-1210 cells: K. Ohno & M. Hirata; Biochem. Biophys. Res. Commun. 168, 551 (1990), Abstract

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Prostaglandin A2

BML-PG002

Product Details

Handling & Storage

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