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Propranolol

BML-ST405

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Adrenergic receptor inhibitor

Propranolol blocks PLD derived DAG formation by inhibiting phosphatidate phosphohydrolase (IC₅₀=70 µM). It is a useful tool to discriminate between PLC or PLD mediated DAG production. It is also a β-adrenergic receptor blocking agent.

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Product Details

Appearance	White to off-white powder.
CAS	318-98-9
Couple Target	Adrenergic receptor, Phospholipase, PLD
Couple Type	Inhibitor
Formula	C₁₆H₂₁NO₂ . HCl
Identity	Determined by 1H-NMR and LC-MS.
MW	295.8
Purity	≥98% (HPLC)
Solubility	Soluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

ER stress inhibition enhances formation of triacylglcerols and protects endothelial cells from lipotoxicity: I. Kovacevic, et al.; Cell Commun. Signal. 22, 304 (2024), Abstract
The effect of mTOR activation and PTEN inhibition on human primordial follicle activation in ovarian tissue culture: Ghezelayagh, Z., Abtahi, N. S., et al.; J. Assist. Reprod. Genet. 39, 1739 (2022), Abstract
New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators: X. Sun, et al.; Cell Cycle 14, 721 (2015), Abstract — Full Text
Exogenous norepinephrine attenuates the efficacy of sunitinib in a mouse cancer model: Deng, G. H., Liu, J., et al.; J. Exp. Clin. Cancer Res. 33, 21 (2014), Abstract
Receptor-coupled phospholipase D and its inhibition: N.T. Thompson, et al.; Trends Pharmacol. Sci. 12, 404 (1991), Abstract
Regulation of phospholipase D in HL-60 granulocytes. Activation by phorbol esters, diglyceride, and calcium ionophore via protein kinase- independent mechanisms: M. M. Billah, et al.; J. Biol. Chem. 264, 9069 (1989), Abstract — Full Text
The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias: A. M. Barrett, et al.; Br. J. Pharmacol. 34, 43 (1968), Abstract — Full Text

Last modified: May 29, 2024

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Propranolol

BML-ST405

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