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Progranulin (PGRN) has been shown to be a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signalling cascades that control cell cycle progression and cell motility. PGRN has also been linked to tumorigenesis. The function of PGRN in the central nervous system (CNS) is also of interest, because mutations in the PGRN gene have been identified in cases of frontotemporal degeneration (FTD).
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| Regulatory Status |
RUO – Research Use Only |
|---|
Related Products
| Alternative Name | Proepithelin, PEPI, PC cell-derived growth factor |
|---|---|
| Purity | ≥90% (SDS-PAGE) |
| Source | Produced in mouse myeloma cell line, NS0-derived. Mouse progranulin (aa 18-589) is fused at the C-terminus with a His-tag. |
Last modified: May 29, 2024