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Collagen type II is the most abundant protein of cartilage matrix. Two isoforms exist, and collagen type IIA is involved in early development of cartilage in embryos. The collagen is produced from type II procollagen when two teloterminal propeptides are digested from the procursor and released into the circulation. Procollagen type II N-terminal propeptide (PIIANP) is considered a marker of cartilage synthesis, and the normal concentration in serum is approximately 30 ng/mL.
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Figure 2: Immunohistochemical analysis of formalin-fixed, paraffin-embedded biopsy from a chondroblastoma, showing specific staining of tumor cells using Procollagen type IIA (NT) (human), mAb and developed with peroxidase-labeled goat anti-mouse Ig (blue color).
Figure 1: Immunohistochemical analysis of formalin-fixed, paraffin-embedded fetal bone anlage in the hand (around week 10) stained using Procollagen type IIA (NT).
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