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Pristimerin

ALX-350-411

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Antitumor agent

Triterpenoid. Antitumor agent. Induces caspase-dependent apoptosis by inhibiting the chymotrypsin-like activity of the proteasome. Inhibits NF-κB activation via inhibition of IKKα or IKKβ. Inhibits induction of inducible nitric oxide synthase (iNOS; NOS II). Shows in vitro antimalarial and insecticidal activity. Induces mitochondrial cell death. Has antiproliferative, antifungal and antiviral properties. Potent and reversible monoacylglycerol lipase (MGL) inhibitor.

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Product Details

Alternative Name	Celastrol methyl ester
Appearance	Orange crystalline solid.
CAS	1258-84-0
Couple Target	Monoacylglycerol lipase, NOS
Couple Type	Inhibitor
Formula	C₃₀H₄₀O₄
Identity	Determined by IR.
MI	14: 10370
MW	464.6
Purity	≥97% (HPLC)
Solubility	Soluble in DMSO or ethyl acetate; insoluble in water.
Source	Isolated from Tripterygium wilfordii Hook.F.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Pristimerin Inhibits Prostate Cancer Bone Metastasis by Targeting PC-3 Stem Cell Characteristics and VEGF-Induced Vasculogenesis of BM-EPCs: S. Huang, et al.; Cell. Physiol. Biochem. 37, 253 (2015), Application(s): Cell culture, Abstract — Full Text
Discovery of potent and reversible monoacylglycerol lipase inhibitors: A.R. King, et al.; Chem. Biol. 16, 1045 (2009), Abstract
Triterpenoids as new promising anticancer drugs: A. Petronelli, et al.; Anticancer Drugs 20, 880 (2009), Abstract
Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells: J.Y. Byun, et al.; Mol. Pharmacol. 76, 734 (2009), Abstract
Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo: R.E. Tiedemann, et al.; Blood 113, 4027 (2009), Abstract
Antiproliferative activity of pristimerin isolated from Maytenus ilicifolia (Celastraceae) in human HL-60 cells: P.M. Costa, et al.; Toxicol. in vitro 22, 854 (2008), Abstract
Pristimerin induces apoptosis by targeting the proteasome in prostate cancer cells: H. Yang, et al.; J. Cell. Biochem. 103, 234 (2008), Abstract
Antigiardial activity of triterpenoids from root bark of Hippocratea excelsa: G.J. Mena-Rejón, et al.; J. Nat. Prod. 70, 863 (2007), Abstract
Anticytomegalovirus activity of pristimerin, a triterpenoid quinone methide isolated from Maytenus heterophylla (Eckl. & Zeyh.): T. Murayama, et al.; Antivir. Chem. Chemother. 18, 133 (2007), Abstract
Pristimerin induces caspase-dependent apoptosis in MDA-MB-231 cells via direct effects on mitochondria: C.C. Wu, et al.; Mol. Cancer Ther. 4, 1277 (2005), Abstract — Full Text

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Alternative Name	Tripterine, 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic acid
CAS	34157-83-0
Couple Type	Inhibitor
Purity	≥98% (HPLC)

Last modified: May 29, 2024

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Pristimerin

ALX-350-411

Product Details

Handling & Storage

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