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Pregnenolone-16α-carbonitrile

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Cytochrome P450 inducer

Cytochrome P-450 inducer. Activates transcription of the PCN1 gene. SXR/PXR Ligand.

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Alternative Name	U-14975
Appearance	White to off-white solid.
CAS	1434-54-4
Couple Target	Cytochrome P450, PXR
Couple Type	Activator, Ligand
Formula	C₂₂H₃₁NO₂
MW	341.5
Purity	≥99% (HPLC)
Solubility	Soluble in DMF (5mg/ml) or acetone (1mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Source-Related Effects of Wastewater on Transcription Factor (AhR, CAR and PXR)-Mediated Induction of Gene Expression in Cultured Rat Hepatocytes and Their Association with the Prevalence of Antimicrobial-Resistant Escherichia coli: K.S. Guruge, et al.; PLoS One 10, e0138391 (2015), Application(s): Cell Culture, Abstract — Full Text

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