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PR-619 is a non-selective, reversible inhibitor of deubiquitinases/deubiquitylases (DUBs) and ubiquitin-like isopeptidases. PR-619 inhibits many deubiquitinating enzymes in the 5-20 µM range. Additionally, PR-619 is cell-permeable and treatment of cells results in the accumulation of both ubiquitin and sumo-conjugated proteins.
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RUO – Research Use Only |
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